Hussain Badra, Khan Sadia, Agger Anne Eriksson, Ellingsen Jan Eirik, Lyngstadaas Ståle Petter, Bueno Jaime, Haugen Håvard J
Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317 Oslo, Norway.
Department of Prosthetics and Oral Function, Institute of Clinical Dentistry, University of Oslo, 0317 Oslo, Norway.
J Funct Biomater. 2023 Jul 25;14(8):394. doi: 10.3390/jfb14080394.
Surface chemistry evaluation is crucial in assessing the efficacy of chemical decontamination products for titanium implants. This study aimed to investigate the effectiveness of chemical decontamination solutions in cleaning a contaminated dental implant surface and to evaluate the potential of combining Pluronic gel with hydrogen peroxide (NuBoneClean) by evaluating pellicle disruption and re-formation on implant surfaces. In addition, ensuring safety with in vitro and human testing protocols. X-ray Photoelectron Spectroscopy (XPS) was utilised for surface analysis. All the tested gels had some effect on the surface cleanness except for PrefGel. Among the tested chemical decontamination candidates, NuBoneClean demonstrated effectiveness in providing a cleaner titanium surface. Furthermore, none of the tested chemical agents exhibited cytotoxic effects, and the safety assessment showed no adverse events. The results of this study highlight the significance of conducting comprehensive evaluations, encompassing safety and efficacy, before introducing new chemical agents for dental treatments. The findings suggest that NuBoneClean shows potential as a chemical decontamination solution for implant surfaces. However, further investigation through randomised clinical trials is necessary. By adhering to rigorous testing protocols, the development of safe and efficient chemical decontamination strategies can be advanced, benefiting patients and promoting progress in implant dentistry.
表面化学评估对于评估钛植入物化学去污产品的功效至关重要。本研究旨在调查化学去污溶液清洁受污染牙种植体表面的有效性，并通过评估种植体表面的薄膜破坏和重新形成来评估将普朗尼克凝胶与过氧化氢（NuBoneClean）结合使用的潜力。此外，通过体外和人体测试方案确保安全性。利用X射线光电子能谱（XPS）进行表面分析。除了PrefGel之外，所有测试的凝胶对表面清洁度都有一定影响。在测试的化学去污候选物中，NuBoneClean在提供更清洁的钛表面方面表现出有效性。此外，测试的化学试剂均未表现出细胞毒性作用，安全性评估也未显示不良事件。本研究结果突出了在引入用于牙科治疗的新化学试剂之前进行包括安全性和有效性在内的综合评估的重要性。研究结果表明，NuBoneClean作为种植体表面化学去污溶液具有潜力。然而，有必要通过随机临床试验进行进一步研究。通过遵循严格的测试方案，可以推进安全有效的化学去污策略的开发，使患者受益并促进种植牙科的发展。
