Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, China.
Pharm Biol. 2022 Dec;60(1):1088-1094. doi: 10.1080/13880209.2022.2074057.
Aucubin (AU), an iridoid glycoside that is one of the active constituents of Oliv. (EUO) (Eucommiaceae), a traditional Chinese medicine, has been extensively studied in the management of neurological diseases (NDs). However, a comprehensive review of its effects and mechanisms in this regard is currently not available.
To compile the protective effects and mechanisms of AU in NDs and provide a basis for further research.
We used 'aucubin' as the 'All Fields' or 'MeSH' in PubMed, Web of Science and China National Knowledge Infrastructure without any limitation to search all relevant articles as comprehensively as possible; we selected the articles on AU treatment of NDs for summary.
Studies reviewed herein reported that AU improved the symptoms or prognosis of Parkinson's disease, Alzheimer's disease, intracerebral haemorrhage, diabetic encephalopathy, epilepsy, anxiety and depression, and traumatic brain injury. The pharmacological mechanisms involved in repairing neuronal loss were postulated to include increasing γ-aminobutyric acid (GABA) content in the synapse, promoting differentiation of neural precursor cells into GABAergic neurons, providing antioxidant and anti-neuroinflammation activities, as well as enhancing autophagy and anti-apoptotic actions.
The protective effects of AU on some NDs have been confirmed. According to the pharmacological effects, AU is also highly likely to have protective effects on other NDs, which can be realized by further and basic research, and clinical trials. In the future, AU may be used for clinical prevention or treatment of patients with neurological diseases.
桃叶珊瑚苷（AU）是一种环烯醚萜糖苷，是传统中药杜仲（EUO）（杜仲科）的活性成分之一，已广泛研究用于治疗神经退行性疾病（NDs）。然而，目前尚缺乏关于其在这方面的作用和机制的综合综述。
编译 AU 在 NDs 中的保护作用和机制，为进一步研究提供依据。
我们在 PubMed、Web of Science 和中国国家知识基础设施中，以“aucubin”作为“All Fields”或“MeSH”，不加任何限制地进行全面搜索，尽可能全面地搜索所有相关文章；我们选择了 AU 治疗 NDs 的文章进行总结。
综述中报道的研究表明，AU 改善了帕金森病、阿尔茨海默病、脑出血、糖尿病性脑病、癫痫、焦虑和抑郁以及创伤性脑损伤的症状或预后。推测其修复神经元丢失的药理机制包括增加突触中γ-氨基丁酸（GABA）的含量、促进神经前体细胞分化为 GABA 能神经元、提供抗氧化和抗神经炎症作用以及增强自噬和抗细胞凋亡作用。
AU 对一些 NDs 的保护作用已得到证实。根据药理作用，AU 也极有可能对其他 NDs 具有保护作用，可以通过进一步的基础研究和临床试验来实现。未来，AU 可能用于临床预防或治疗神经疾病患者。
