Axelsson I, Jakobsson I, Lindberg T, Benediktsson B
Acta Paediatr Scand. 1986 Sep;75(5):702-7. doi: 10.1111/j.1651-2227.1986.tb10277.x.
Human milk samples (n = 232) collected during the whole lactation period from 25 healthy, Swedish mothers were analyzed by radioimmunologic method for content of bovine beta-lactoglobulin. Detectable amounts (5-800 micrograms/l) were found in 93 of 232 milk samples (40%). Six mothers had no detectable beta-lactoglobulin in their breast milk on any occasion. Two mothers had measurable beta-lactoglobulin in all their milk samples. No correlation was found between daily cow's milk intake and concentration of beta-lactoglobulin in the milk samples. Six mothers with allergic symptoms such as asthma, hay-fever, eczema all had detectable amounts of beta-lactoglobulin in their milk. Of 19 mothers without allergy, 13 had detectable amounts. This difference did not show statistical significance. The presence of symptoms in the infant such as diarrhoea, vomiting, colic, exanthema was significantly correlated to high levels of beta-lactoglobulin in the milk. Bovine beta-lactoglobulin was also detected in 7 of 13 serum samples. The two mothers with detectable beta-lactoglobulin in all milk samples had the highest serum values, and their infants suffered from gastro-intestinal symptoms, weight decline and exanthema.
采用放射免疫法对25名健康瑞典母亲在整个哺乳期采集的232份母乳样本进行了牛β-乳球蛋白含量分析。在232份母乳样本中的93份（40%）检测到了可检测量（5 - 800微克/升）。6名母亲在任何时候的母乳中都未检测到β-乳球蛋白。2名母亲的所有母乳样本中β-乳球蛋白均可测量。母乳样本中β-乳球蛋白浓度与每日牛奶摄入量之间未发现相关性。6名有哮喘、花粉热、湿疹等过敏症状的母亲，其母乳中均检测到了可检测量的β-乳球蛋白。在19名无过敏症状的母亲中，有13名检测到了可检测量。这种差异无统计学意义。婴儿出现腹泻、呕吐、腹痛、皮疹等症状与母乳中高水平的β-乳球蛋白显著相关。在13份血清样本中的7份也检测到了牛β-乳球蛋白。在所有母乳样本中均可检测到β-乳球蛋白的2名母亲，其血清值最高，她们的婴儿出现了胃肠道症状、体重下降和皮疹。
