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基于3D打印支架的骨肉瘤模型能够在体外模拟骨微环境中研究肿瘤表型和发病机制。

A 3D-printed scaffold-based osteosarcoma model allows to investigate tumor phenotypes and pathogenesis in an in vitro bone-mimicking niche.

作者信息

Wang Mei-Ling, Xu Nian-Yuan, Tang Rui-Zhi, Liu Xi-Qiu

机构信息

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China.

Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China.

出版信息

Mater Today Bio. 2022 May 25;15:100295. doi: 10.1016/j.mtbio.2022.100295. eCollection 2022 Jun.

DOI:10.1016/j.mtbio.2022.100295
PMID:35665234
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9161108/
Abstract

Image 1.

摘要

图1。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/2d44e6f91126/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/246ecd520703/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/f8b454d7d9df/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/aa9f8f236b67/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/92d7b1f0811e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/62ebbd511398/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/71ebdf4a4692/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/90996775cafd/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/8293618b9e2c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/2d44e6f91126/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/246ecd520703/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/f8b454d7d9df/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/aa9f8f236b67/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/92d7b1f0811e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/62ebbd511398/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/71ebdf4a4692/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/90996775cafd/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/8293618b9e2c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1491/9161108/2d44e6f91126/gr7.jpg

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本文引用的文献

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Oncoimmunology. 2021 Sep 24;10(1):1966969. doi: 10.1080/2162402X.2021.1966969. eCollection 2021.
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Expression of in surgical specimen and biopsy as a biomarker of metastasis in patients with osteosarcoma: a meta-analysis.骨肉瘤患者手术标本和活检中 作为转移生物标志物的表达：一项荟萃分析。 （注：原文中“Expression of ”这里“of”后面缺少具体内容）
Transl Cancer Res. 2019 Aug;8(4):1129-1136. doi: 10.21037/tcr.2019.06.26.
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骨肉瘤中优势浸润免疫细胞类型的新基因特征可预测总生存期。
Sci Rep. 2023 Oct 25;13(1):18271. doi: 10.1038/s41598-023-45566-6.
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Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine.骨肉瘤模型在药物发现和精准医学中的研究进展
Biomolecules. 2023 Sep 7;13(9):1362. doi: 10.3390/biom13091362.
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Mater Today Bio. 2023 Mar 8;19:100607. doi: 10.1016/j.mtbio.2023.100607. eCollection 2023 Apr.
Bioengineering a humanized 3D tri-culture osteosarcoma model to assess tumor invasiveness and therapy response.
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Engineering strategies to capture the biological and biophysical tumor microenvironment in vitro.体外捕获生物和生物物理肿瘤微环境的工程策略。
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