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一种来自牛肝脏的新型酰基辅酶A结合蛋白。对脂肪酸合成的影响。

A novel acyl-CoA-binding protein from bovine liver. Effect on fatty acid synthesis.

作者信息

Mogensen I B, Schulenberg H, Hansen H O, Spener F, Knudsen J

出版信息

Biochem J. 1987 Jan 1;241(1):189-92. doi: 10.1042/bj2410189.

DOI:10.1042/bj2410189
PMID:3566708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1147542/
Abstract

Bovine liver was shown to contain a hitherto undescribed medium-chain acyl-CoA-binding protein. The protein co-purifies with fatty-acid-binding proteins, but was, unlike these proteins, unable to bind fatty acids. The protein induced synthesis of medium-chain acyl-CoA esters on incubation with goat mammary-gland fatty acid synthetase. The possible function of the protein is discussed.

摘要

已证明牛肝脏中含有一种迄今未被描述的中链酰基辅酶A结合蛋白。该蛋白与脂肪酸结合蛋白共纯化，但与这些蛋白不同的是，它不能结合脂肪酸。该蛋白在与山羊乳腺脂肪酸合成酶一起孵育时可诱导中链酰基辅酶A酯的合成。文中讨论了该蛋白可能的功能。

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1
A novel acyl-CoA-binding protein from bovine liver. Effect on fatty acid synthesis.一种来自牛肝脏的新型酰基辅酶A结合蛋白。对脂肪酸合成的影响。
Biochem J. 1987 Jan 1;241(1):189-92. doi: 10.1042/bj2410189.
2
Transacylation as a chain-termination mechanism in fatty acid synthesis by mammalian fatty acid synthetase. Synthesis of medium-chain-length (C8-C12) acyl-CoA esters by goat mammary-gland fatty acid synthetase.转酰基作用作为哺乳动物脂肪酸合成酶催化脂肪酸合成过程中的链终止机制。山羊乳腺脂肪酸合成酶催化中链长度（C8 - C12）酰基辅酶A酯的合成。
Biochem J. 1982 Jan 15;202(1):139-43. doi: 10.1042/bj2020139.
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Medium-chain fatty acid synthesis by goat mammary-gland fatty acid synthetase. The effect of limited proteolysis.山羊乳腺脂肪酸合成酶合成中链脂肪酸。有限蛋白酶解的影响。
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4
Medium-chain fatty acid synthesis in lactating-rabbit mammary gland. Intracellular concentration and specificity of medium-chain acyl thioester hydrolase.泌乳兔乳腺中中链脂肪酸的合成。中链酰基硫酯水解酶的细胞内浓度及特异性。
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Transacylation as a chain-termination mechanism in fatty acid synthesis by mammalian fatty acid synthetase. Synthesis of butyrate and hexanoate by lactating cow mammary gland fatty acid synthetase.转酰基作用作为哺乳动物脂肪酸合成酶脂肪酸合成中的链终止机制。泌乳奶牛乳腺脂肪酸合成酶合成丁酸和己酸。
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From benzodiazepines to fatty acids and beyond: revisiting the role of ACBP/DBI.从苯二氮䓬类药物到脂肪酸类药物，以及更多：重新探讨 ACBP/DBI 的作用。

本文引用的文献

1
[On the biosynthesis of fatty acids. II. Synthesis and properties of S-malonyl-coenzyme A].[关于脂肪酸的生物合成。II. S-丙二酰辅酶A的合成与性质]
Biochem Z. 1962;335:540-7.
2
Transacylation as a chain-termination mechanism in fatty acid synthesis by mammalian fatty acid synthetase. Synthesis of medium-chain-length (C8-C12) acyl-CoA esters by goat mammary-gland fatty acid synthetase.转酰基作用作为哺乳动物脂肪酸合成酶催化脂肪酸合成过程中的链终止机制。山羊乳腺脂肪酸合成酶催化中链长度（C8 - C12）酰基辅酶A酯的合成。
Biochem J. 1982 Jan 15;202(1):139-43. doi: 10.1042/bj2020139.
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Triacylglycerol synthesis in goat mammary gland. Factors influencing the esterification of fatty acids synthesized de novo.
Trends Endocrinol Metab. 2021 Nov;32(11):890-903. doi: 10.1016/j.tem.2021.08.009. Epub 2021 Sep 23.
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Cytoprotective and Neurotrophic Effects of Octadecaneuropeptide (ODN) in and Models of Neurodegenerative Diseases.十八烷脑啡肽（ODN）在神经退行性疾病动物模型中的细胞保护和神经营养作用。
Front Endocrinol (Lausanne). 2020 Nov 4;11:566026. doi: 10.3389/fendo.2020.566026. eCollection 2020.
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Glial Endozepines Inhibit Feeding-Related Autonomic Functions by Acting at the Brainstem Level.胶质内啡肽通过作用于脑干水平来抑制与进食相关的自主功能。
Front Neurosci. 2017 May 30;11:308. doi: 10.3389/fnins.2017.00308. eCollection 2017.
6
Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice.含酰基辅酶A结合结构域7参与小鼠食物摄入和能量消耗的调控。
Elife. 2016 Feb 15;5:e11742. doi: 10.7554/eLife.11742.
7
Deciphering the roles of acyl-CoA-binding proteins in plant cells.解析酰基辅酶A结合蛋白在植物细胞中的作用。
Protoplasma. 2016 Sep;253(5):1177-95. doi: 10.1007/s00709-015-0882-6. Epub 2015 Sep 4.
8
Compromised epidermal barrier stimulates Harderian gland activity and hypertrophy in ACBP-/- mice.受损的表皮屏障会刺激 ACBP-/- 小鼠的哈德氏腺活动及肥大。
J Lipid Res. 2015 Sep;56(9):1738-46. doi: 10.1194/jlr.M060780. Epub 2015 Jul 4.
9
Endozepines.内啡肽
Adv Pharmacol. 2015;72:147-64. doi: 10.1016/bs.apha.2014.10.005. Epub 2014 Dec 4.
10
Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer.酰基辅酶A结合蛋白调节非小细胞肺癌生长和存活所需的β-氧化。
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山羊乳腺中的三酰甘油合成。影响从头合成脂肪酸酯化的因素。
Biochem J. 1984 Jun 1;220(2):521-7. doi: 10.1042/bj2200521.
4
Fatty-acid-binding proteins. Occurrence of two fatty-acid-binding proteins in bovine liver cytosol and their binding of fatty acids, cholesterol, and other lipophilic ligands.脂肪酸结合蛋白。牛肝细胞溶质中两种脂肪酸结合蛋白的存在及其与脂肪酸、胆固醇和其他亲脂性配体的结合。
Hoppe Seylers Z Physiol Chem. 1984 Mar;365(3):365-76. doi: 10.1515/bchm2.1984.365.1.365.
5
Triacylglycerol synthesis in goat mammary gland. The effect of ATP, Mg2+ and glycerol 3-phosphate on the esterification of fatty acids synthesized de novo.山羊乳腺中三酰甘油的合成。ATP、Mg2+和3-磷酸甘油对从头合成的脂肪酸酯化作用的影响。
Biochem J. 1984 Jun 1;220(2):513-9. doi: 10.1042/bj2200513.
6
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
7
Fatty acid synthetase from cow mammary gland tissue cells.来自奶牛乳腺组织细胞的脂肪酸合成酶。
Biochim Biophys Acta. 1972 Nov 30;280(3):408-14. doi: 10.1016/0005-2760(72)90246-9.
8
Stimulation of monoacylglycerophosphate formation by Z protein.Z蛋白对单酰甘油磷酸形成的刺激作用。
Biochem Biophys Res Commun. 1974 Sep 9;60(1):376-81. doi: 10.1016/0006-291x(74)90215-0.
9
Function and regulation of hepatic and intestinal fatty acid binding proteins.肝脏和肠道脂肪酸结合蛋白的功能与调节
Chem Phys Lipids. 1985 Aug 30;38(1-2):95-114. doi: 10.1016/0009-3084(85)90060-x.
10
Spectroscopic investigations on the binding site of bovine hepatic fatty acid binding protein. Evidence for the existence of a single binding site for two fatty acid molecules.牛肝脏脂肪酸结合蛋白结合位点的光谱学研究。存在两个脂肪酸分子的单一结合位点的证据。
Chem Phys Lipids. 1985 Aug 30;38(1-2):159-73. doi: 10.1016/0009-3084(85)90064-7.