Wang Bei, Yan Lingling, Guo Shuchen, Wen Ling, Yu Mengli, Feng Liang, Jia Xiaobin
State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Front Nutr. 2022 May 20;9:908175. doi: 10.3389/fnut.2022.908175. eCollection 2022.
Chinese herbal polysaccharides (CHPs) are natural polymers composed of monosaccharides, which are widely found in Chinese herbs and work as one of the important active ingredients. Its biological activity is attributed to its complex chemical structure with diverse spatial conformations. However, the structural elucidation is the foundation but a bottleneck problem because the majority of CHPs are heteropolysaccharides with more complex structures. Similarly, the studies on the relationship between structure and function of CHPs are even more scarce. Therefore, this review summarizes the structure-activity relationship of CHPs. Meanwhile, we reviewed the structural elucidation strategies and some new progress especially in the advanced structural analysis methods. The characteristics and applicable scopes of various methods are compared to provide reference for selecting the most efficient method and developing new hyphenated techniques. Additionally, the principle structural modification methods of CHPs and their effects on activity are summarized. The shortcomings, potential breakthroughs, and developing directions of the study of CHPs are discussed. We hope to provide a reference for further research and promote the application of CHPs.
中草药多糖（CHPs）是由单糖组成的天然聚合物，广泛存在于中草药中，是重要的活性成分之一。其生物活性归因于其具有多样空间构象的复杂化学结构。然而，结构解析是基础但也是一个瓶颈问题，因为大多数CHPs是结构更为复杂的杂多糖。同样，关于CHPs结构与功能关系的研究更为稀少。因此，本综述总结了CHPs的构效关系。同时，我们回顾了结构解析策略以及一些新进展，特别是在先进结构分析方法方面。比较了各种方法的特点和适用范围，为选择最有效的方法和开发新的联用技术提供参考。此外，总结了CHPs的主要结构修饰方法及其对活性的影响。讨论了CHPs研究的不足、潜在突破和发展方向。我们希望为进一步研究提供参考并促进CHPs的应用。
