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利用医学影像进行肺癌和结肠癌分类:一种特征工程方法。

Lung and colon cancer classification using medical imaging: a feature engineering approach.

机构信息

LARIS, SFR MATHSTIC, Univ Angers, Angers, France.

LaTIM, INSERM, UMR 1101, Univ Brest, Brest, France.

出版信息

Phys Eng Sci Med. 2022 Sep;45(3):729-746. doi: 10.1007/s13246-022-01139-x. Epub 2022 Jun 7.

Abstract

Lung and colon cancers lead to a significant portion of deaths. Their simultaneous occurrence is uncommon, however, in the absence of early diagnosis, the metastasis of cancer cells is very high between these two organs. Currently, histopathological diagnosis and appropriate treatment are the only way to improve the chances of survival and reduce cancer mortality. Using artificial intelligence in the histopathological diagnosis of colon and lung cancer can provide significant help to specialists in identifying cases of colon and lung cancers with less effort, time and cost. The objective of this study is to set up a computer-aided diagnostic system that can accurately classify five types of colon and lung tissues (two classes for colon cancer and three classes for lung cancer) by analyzing their histopathological images. Using machine learning, features engineering and image processing techniques, the six models XGBoost, SVM, RF, LDA, MLP and LightGBM were used to perform the classification of histopathological images of lung and colon cancers that were acquired from the LC25000 dataset. The main advantage of using machine learning models is that they allow a better interpretability of the classification model since they are based on feature engineering; however, deep learning models are black box networks whose working is very difficult to understand due to the complex network design. The acquired experimental results show that machine learning models give satisfactory results and are very precise in identifying classes of lung and colon cancer subtypes. The XGBoost model gave the best performance with an accuracy of 99% and a F1-score of 98.8%. The implementation and the development of this model will help healthcare specialists identify types of colon and lung cancers. The code will be available upon request.

摘要

肺癌和结肠癌导致了很大一部分的死亡。然而,这两种癌症同时发生的情况并不常见,因为如果不能早期诊断,癌细胞在这两个器官之间转移的几率非常高。目前,组织病理学诊断和适当的治疗是提高生存机会和降低癌症死亡率的唯一方法。在结肠癌和肺癌的组织病理学诊断中使用人工智能可以为专家提供很大的帮助,使他们能够更轻松、更快速、更节省成本地识别结肠癌和肺癌病例。本研究的目的是建立一个计算机辅助诊断系统,通过分析其组织病理学图像,准确地对五种类型的结肠癌和肺癌组织进行分类(结肠癌两类,肺癌三类)。该系统使用机器学习、特征工程和图像处理技术,使用 XGBoost、SVM、RF、LDA、MLP 和 LightGBM 这 6 个模型对来自 LC25000 数据集的肺癌和结肠癌组织的病理图像进行分类。使用机器学习模型的主要优点是,它们允许对分类模型进行更好的解释,因为它们基于特征工程;但是,深度学习模型是黑盒网络,由于网络设计复杂,其工作原理很难理解。所获得的实验结果表明,机器学习模型在识别肺癌和结肠癌亚型方面给出了令人满意的结果,并且非常精确。XGBoost 模型的性能最佳,准确率为 99%,F1 得分为 98.8%。该模型的实现和开发将有助于医疗保健专家识别结肠癌和肺癌的类型。如有需要,可以提供代码。

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