Materials and Nanotechnology Program, North Dakota State University, Fargo, North Dakota 58108, United States.
Biomedical Engineering Program, North Dakota State University, Fargo, North Dakota 58108, United States.
ACS Biomater Sci Eng. 2023 May 8;9(5):2103-2128. doi: 10.1021/acsbiomaterials.1c01208. Epub 2022 Jun 9.
Wearable, point-of-care diagnostics, and biosensors are on the verge of bringing transformative changes in detection, management, and treatment of cancer. Bioinspired materials with new forms and functions have frequently been used, in both translational and commercial spaces, to fabricate such diagnostic platforms. Engineered from organic or inorganic molecules, bioinspired systems are naturally equipped with biorecognition and stimuli-sensitive properties. Mechanisms of action of bioinspired materials are deeply connected with thermodynamically or kinetically controlled self-assembly at the molecular and supramolecular levels. Thus, integration of bioinspired materials into wearable devices, either as triggers or sensors, brings about unique device properties usable for detection, capture, or rapid readout for an analyte of interest. In this review, we present the basic principles and mechanisms of action of diagnostic devices engineered from bioinspired materials, describe current advances, and discuss future trends of the field, particularly in the context of cancer.
可穿戴、即时诊断和生物传感器即将带来癌症检测、管理和治疗方面的变革。在转化和商业领域，具有新形式和功能的仿生材料经常被用于制造此类诊断平台。仿生系统由有机或无机分子工程化而成，天生具有生物识别和刺激敏感特性。仿生材料的作用机制与分子和超分子水平上热力学或动力学控制的自组装密切相关。因此，将仿生材料集成到可穿戴设备中，无论是作为触发器还是传感器，都能带来独特的设备特性，可用于检测、捕获或快速读取感兴趣的分析物。在这篇综述中，我们介绍了由仿生材料设计的诊断设备的基本原理和作用机制，描述了当前的进展，并讨论了该领域的未来趋势，特别是在癌症方面。
