Zhang Ying-Ying, Zhang Wen-Ya, Xin Xiao-Hong, Du Pu-Feng
College of Intelligence and Computing, Tianjin University, Tianjin 300350, China.
Comput Struct Biotechnol J. 2022 May 23;20:2657-2663. doi: 10.1016/j.csbj.2022.05.043. eCollection 2022.
Long non-coding RNAs (lncRNAs) play important roles in many biological processes. Knocking out or knocking down some lncRNAs will lead to lethality or infertility. These lncRNAs are called essential lncRNAs. Knowledges of essential lncRNAs are important in establishing minimal genomes of living cells, developing drug therapies and early diagnostic approaches for complex diseases. However, existing databases focus on collecting essential coding genes. Essential non-coding gene records are rare in existing databases. A comprehensive collection of essential non-coding genes, particularly essential lncRNA genes, is demanded. We manually curated 207 essential lncRNAs from literatures for establishing a database on essential lncRNAs, which is named as dbEssLnc (Database of essential lncRNAs). The dbEssLnc database has a web-based user-friendly interface for the users to browse, to search, to visualize and to blast search records in the database. The dbEssLnc database is freely accessible at https://esslnc.pufengdu.org. All data and source codes for mirroring the dbEssLnc database have been deposited in GitHub (https://github.com/yyZhang14/dbEssLnc).
长链非编码RNA（lncRNAs）在许多生物学过程中发挥着重要作用。敲除或降低某些lncRNAs会导致致死性或不育。这些lncRNAs被称为必需lncRNAs。必需lncRNAs的知识对于建立活细胞的最小基因组、开发复杂疾病的药物治疗方法和早期诊断方法具有重要意义。然而，现有数据库主要集中于收集必需编码基因。现有数据库中必需非编码基因的记录很少。因此，需要全面收集必需非编码基因，特别是必需lncRNA基因。我们从文献中人工筛选了207个必需lncRNAs，用于建立一个必需lncRNAs数据库，命名为dbEssLnc（必需lncRNAs数据库）。dbEssLnc数据库有一个基于网络的用户友好界面，供用户浏览、搜索、可视化和在数据库中进行blast搜索记录。dbEssLnc数据库可在https://esslnc.pufengdu.org免费访问。用于镜像dbEssLnc数据库的所有数据和源代码已存放在GitHub（https://github.com/yyZhang14/dbEssLnc）上。
