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Obstructive sleep apnea may increase the risk of Alzheimer's disease.阻塞性睡眠呼吸暂停可能会增加患阿尔茨海默病的风险。
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Progressive tauopathy disrupts breathing stability and chemoreflexes during presumptive sleep in mice.进行性tau蛋白病会破坏小鼠假定睡眠期间的呼吸稳定性和化学反射。
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Using machine learning to extract cognitive status from the sleep EEG in progressing stages of dementia: defining interpretable and age-related features.利用机器学习从痴呆症进展阶段的睡眠脑电图中提取认知状态：定义可解释的与年龄相关的特征。
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1
Head-to-Head Comparison of 8 Plasma Amyloid-β 42/40 Assays in Alzheimer Disease.阿尔茨海默病中 8 种血浆淀粉样蛋白β 42/40 分析物的对头比较。
JAMA Neurol. 2021 Nov 1;78(11):1375-1382. doi: 10.1001/jamaneurol.2021.3180.
2
Associations of longitudinal plasma p-tau181 and NfL with tau-PET, Aβ-PET and cognition.纵向血浆 p-tau181 和 NfL 与 tau-PET、Aβ-PET 和认知的关联。
J Neurol Neurosurg Psychiatry. 2021 Dec;92(12):1289-1295. doi: 10.1136/jnnp-2020-325537. Epub 2021 Jun 29.
3
Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults.血浆神经丝轻链与非痴呆老年人大脑认知能力下降有关。
Sci Rep. 2021 Jun 28;11(1):13394. doi: 10.1038/s41598-021-91038-0.
4
Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men.急性睡眠缺失对年轻男性中枢神经系统健康生物标志物日间血浆动力学的影响。
Neurology. 2020 Mar 17;94(11):e1181-e1189. doi: 10.1212/WNL.0000000000008866. Epub 2020 Jan 8.
5
Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes.阻塞性睡眠呼吸暂停与阿尔茨海默病纵向生物标志物变化。
Sleep. 2019 Jun 11;42(6). doi: 10.1093/sleep/zsz048.
6
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.睡眠-觉醒周期调节小鼠脑间质液 tau 和人类 CSF tau。
Science. 2019 Feb 22;363(6429):880-884. doi: 10.1126/science.aav2546. Epub 2019 Jan 24.
7
Obstructive sleep apnea treatment, slow wave activity, and amyloid-β.阻塞性睡眠呼吸暂停治疗、慢波活动与淀粉样β。
Ann Neurol. 2019 Feb;85(2):291-295. doi: 10.1002/ana.25408. Epub 2019 Jan 17.
8
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.NIA-AA 研究框架：迈向阿尔茨海默病的生物学定义。
Alzheimers Dement. 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018.
9
Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics.睡眠对夜间脑脊液淀粉样蛋白 β 动力学的影响。
Ann Neurol. 2018 Jan;83(1):197-204. doi: 10.1002/ana.25117.
10
Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study.阻塞性睡眠呼吸暂停严重程度影响认知正常老年人的淀粉样蛋白负担：一项纵向研究。
Am J Respir Crit Care Med. 2018 Apr 1;197(7):933-943. doi: 10.1164/rccm.201704-0704OC.

Acute OSA Impacts Diurnal Alzheimer's Biomarkers through Nocturnal Hypoxemia and State Transitions.

作者信息

Kam Korey, Jun Jonathan, Parekh Ankit, Bubu Omonigho M, Mullins Anna E, Gu Chenjuan, Pham Luu, Wisniewski Thomas M, Rapoport David M, Ayappa Indu, Osorio Ricardo S, Varga Andrew W

机构信息

Icahn School of Medicine at Mount Sinai New York, New York.

Johns Hopkins University Baltimore, Maryland.

出版信息

Am J Respir Crit Care Med. 2022 Oct 15;206(8):1039-1042. doi: 10.1164/rccm.202202-0262LE.

DOI:10.1164/rccm.202202-0262LE
PMID:35696622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12038900/
Abstract
摘要