Department of Conservative Dentistry and Endodontics, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy.
Department of Surgical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy.
Clin Exp Dent Res. 2022 Oct;8(5):1068-1075. doi: 10.1002/cre2.604. Epub 2022 Jun 14.
To assess the periapical status in patients with osteoporosis (OP) treated with denosumab (D), bisphosphonates (BPs), or not on medication, and to understand if these conditions influence the prevalence and the progression of apical periodontitis (AP). MATERIAL AND METHODS: Seventy-six patients with OP alone or treated with D, or BPs, formed the study group (O), and those from 76 patients matched for age and sex, without diseases, and not taking medications, constituted the control (C) in this retrospective case-control study. The data from the complete clinical and radiographic examination, medical history, decayed, missing, and filled teeth (DMFT), and periapical index score (PAI) were recorded for each patient. Wilcoxon rank test, χ , and Student's t test were used as appropriate.
The prevalence of AP was similar in O and C. Furthermore, AP was significantly more frequent in root canal-treated teeth in O patients (p = .03).
OP does not appear to be associated with the development of AP. Moreover, the increased prevalence of AP in root canal-treated teeth in O patients highlights a possible relationship between the healing dynamics of the disease post-therapy and the patients' medication. A larger sample is needed to confirm these findings.
评估骨质疏松症（OP）患者接受地舒单抗（D）、双膦酸盐（BPs）治疗或未接受药物治疗的根尖状态，并了解这些情况是否会影响根尖周炎（AP）的患病率和进展。材料与方法：76 例单独患有 OP 或接受 D 或 BPs 治疗的患者组成研究组（O），76 例年龄和性别匹配、无疾病且未服用药物的患者组成对照组（C）。对每位患者的完整临床和影像学检查、病史、龋齿、缺失和补牙（DMFT）以及根尖指数评分（PAI）数据进行记录。采用 Wilcoxon 秩和检验、χ 2 检验和 Student's t 检验。结果：O 组和 C 组的 AP 患病率相似。此外，O 组根管治疗牙中 AP 的发生率显著更高（p = .03）。结论：OP 似乎与 AP 的发生无关。此外，OP 患者根管治疗牙中 AP 患病率增加，提示疾病治疗后愈合动态与患者用药之间可能存在一定关系。需要更大的样本量来证实这些发现。
