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二eckol抑制细颗粒物10对皮脂腺细胞、外根鞘细胞和预处理小鼠的影响。 （注：原文中“Dieckol”可能有误，不太明确其准确意思，暂按原样翻译）

Dieckol Inhibits the Effects of Particulate Matter 10 on Sebocytes, Outer Root Sheath Cells, and -Pretreated Mice.

作者信息

Kwack Mi Hee, Ha Nam Gyoung, Lee Weon Ju

机构信息

Department of Immunology and BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, Korea.

Department of Dermatology, School of Medicine, Kyungpook National University, Daegu, Korea.

出版信息

Ann Dermatol. 2022 Jun;34(3):182-190. doi: 10.5021/ad.2022.34.3.182. Epub 2022 May 20.

DOI:10.5021/ad.2022.34.3.182
PMID:35721332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9171178/
Abstract

BACKGROUND

Particulate matter (PM) is an air pollutant that can impair the human skin. Antioxidants have been tested to improve PM-induced skin inflammation.

OBJECTIVE

In this study, we investigated the effects of dieckol on PM-induced inflammation on cultured human sebocytes, outer root sheath (ORS) cells, and mice pretreated with .

METHODS

We cultured and treated the sebocytes and ORS cells with 5 µM of dieckol and 100 µg/ml of PM10 for 24 h. The -pretreated mice received 5 µM of dieckol and 100 µg/ml of PM10. We measured cell viability using MTT assay. Real-time PCR and measurement of reactive oxygen species (ROS) and sebum production analyzed the effects.

RESULTS

Dieckol inhibited the upregulation of the gene expression of the inflammatory cytokines, matrix metalloproteinase (MMP), aryl hydrocarbon receptor, and nuclear factor kappa-light-chain-enhancer of activated B cells by PM10 in the cultured sebocytes and ORS cells and inhibited an increase in ROS production by PM10 in the cultured sebocytes. In addition, dieckol decreased the inflammatory cytokines, MMP, and sebum production in -pretreated mice.

CONCLUSION

Dieckol effectively reduced the expression of inflammatory biomarkers and the production of sebum in cultured sebocytes, ORS cells, and -pretreated mice.

摘要

背景

颗粒物（PM）是一种可损害人体皮肤的空气污染物。已对抗氧化剂进行测试以改善PM诱导的皮肤炎症。

目的

在本研究中，我们调查了二eck醇对培养的人皮脂腺细胞、外根鞘（ORS）细胞以及经预处理的小鼠中PM诱导的炎症的影响。

方法

我们用5μM二eck醇和100μg/ml PM10培养并处理皮脂腺细胞和ORS细胞24小时。经预处理的小鼠接受5μM二eck醇和100μg/ml PM10。我们使用MTT法测量细胞活力。实时PCR以及活性氧（ROS）和皮脂分泌的测量分析了其效果。

结果

二eck醇抑制了PM10在培养的皮脂腺细胞和ORS细胞中诱导的炎性细胞因子、基质金属蛋白酶（MMP）、芳烃受体和活化B细胞核因子κ轻链增强子的基因表达上调，并抑制了PM10在培养的皮脂腺细胞中诱导的ROS产生增加。此外，二eck醇降低了经预处理小鼠中的炎性细胞因子、MMP和皮脂分泌。

结论

二eck醇有效降低了培养的皮脂腺细胞、ORS细胞以及经预处理小鼠中炎症生物标志物的表达和皮脂分泌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/11efe8933846/ad-34-182-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/3ba237fc063f/ad-34-182-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/d4ba93a7f1b8/ad-34-182-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/4476b21e0ebf/ad-34-182-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/41e228838e34/ad-34-182-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/11efe8933846/ad-34-182-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/3ba237fc063f/ad-34-182-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/d4ba93a7f1b8/ad-34-182-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/4476b21e0ebf/ad-34-182-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/41e228838e34/ad-34-182-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542c/9171178/11efe8933846/ad-34-182-g005.jpg

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