PDCD6 多态性对口腔癌风险的贡献。

The Contribution of PDCD6 Polymorphisms to Oral Cancer Risk.

机构信息

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

出版信息

Cancer Genomics Proteomics. 2022 Jul-Aug;19(4):456-463. doi: 10.21873/cgp.20332.

DOI:10.21873/cgp.20332

PMID:35732318

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9247878/

Abstract

BACKGROUND/AIM: Programmed cell death 6 (PDCD6) is up-regulated and highly expressed in early apoptotic cells. In several types of cancer, such as cervical, breast and lung cancers, the association of PDCD6 genotypes have been investigated. However, the contribution of PDCD6 variant genotypes to oral cancer has never been examined. The current study aimed to evaluate the contribution of the PDCD6 rs4957014 and rs3756712 genotypes to the risk of oral cancer in Taiwan.

PATIENTS AND METHODS

The contribution of PDCD6 genotypes to oral cancer risk was examined among 958 patients with lung cancer and 958 age- and sex-matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP).

RESULTS

The data showed that the hetero-variant GT and homo-variant GG genotypes of PDCD6 rs4957014 were associated with a decreased risk of oral cancer [odds ratio (OR)=0.81 and 0.39, 95% confidence interval (CI)=0.67-0.97 and 0.27-0.56, respectively]. The recessive and dominant models also showed that G carriers have protective effects (OR=0.43 and 0.72, 95% CI=0.30-0.61 and 0.61-0.87, respectively). The analysis of allelic frequency distributions showed that the G allele of PDCD6 rs4957014 was associated with reduced oral cancer risk (OR=0.71, 95% CI=0.62-0.82). There was no significant association between any PDCD6 rs3756712 genotype and oral cancer risk. In addition, the GG genotype at PDCD6 rs4957014 significantly decreased the risk of oral cancer among both males (adjusted OR=0.31, 95%CI=0.24-0.56) and females (adjusted OR=0.44, 95% CI=0.22-0.91). Furthermore, the GG genotype at PDCD6 rs4957014 significantly decreased the risk of oral cancer among smokers (adjusted OR=0.35, 95% CI=0.22-0.58), alcohol drinkers (adjusted OR=0.33, 95% CI=0.18-0.49), non-betel quid chewers (adjusted OR=0.33, 95% CI=0.17- 0.81), betel quid chewers (adjusted OR=0.34, 95% CI=0.21- 0.59), but not among never-smokers and non-alcohol drinkers.

CONCLUSION

The G allele carriers of PDCD6 rs4957014 may have protective effects on oral cancer risk and serve as a practical marker for early detection of oral cancer in Taiwan.

摘要

背景/目的：程序性细胞死亡因子 6（PDCD6）在早期凋亡细胞中呈上调和高表达。在几种类型的癌症中，如宫颈癌、乳腺癌和肺癌，已经研究了 PDCD6 基因型的相关性。然而，PDCD6 变异基因型对口腔癌的贡献从未被检查过。本研究旨在评估 PDCD6 rs4957014 和 rs3756712 基因型在台湾人口腔癌风险中的作用。

患者和方法

通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测 958 例肺癌患者和 958 例年龄和性别匹配的健康对照者中 PDCD6 基因型对口腔癌风险的贡献。

结果

数据显示，PDCD6 rs4957014 的杂合 GT 和纯合 GG 基因型与口腔癌风险降低相关[比值比（OR）=0.81 和 0.39，95%置信区间（CI）=0.67-0.97 和 0.27-0.56]。隐性和显性模型也表明 G 携带者具有保护作用（OR=0.43 和 0.72，95%CI=0.30-0.61 和 0.61-0.87）。等位基因频率分布分析显示，PDCD6 rs4957014 的 G 等位基因与降低的口腔癌风险相关（OR=0.71，95%CI=0.62-0.82）。PDCD6 rs3756712 的任何基因型与口腔癌风险均无显著相关性。此外，PDCD6 rs4957014 的 GG 基因型显著降低了男性（调整后的 OR=0.31，95%CI=0.24-0.56）和女性（调整后的 OR=0.44，95%CI=0.22-0.91）的口腔癌风险。此外，PDCD6 rs4957014 的 GG 基因型还显著降低了吸烟者（调整后的 OR=0.35，95%CI=0.22-0.58）、饮酒者（调整后的 OR=0.33，95%CI=0.18-0.49）、不嚼槟榔者（调整后的 OR=0.33，95%CI=0.17-0.81）、嚼槟榔者（调整后的 OR=0.34，95%CI=0.21-0.59）的口腔癌风险，但对从不吸烟者和非饮酒者无影响。