Shrestha Pami, He Shiying, Legido-Quigley Helena
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
London School of Hygiene and Tropical Medicine, London WC1H 9SH, UK.
Antibiotics (Basel). 2022 Jun 1;11(6):755. doi: 10.3390/antibiotics11060755.
Antimicrobial Resistance is recognized as a major threat to global health security. The WHO Southeast Asia region is dubbed a "global hub for AMR emergence", as it runs the highest risk for AMR emergence among all WHO regions in Asia. Hence, there is a need for Asia-centric, collaborative AMR research aligned with the true needs and priorities of the region. This study aimed to identify and understand the challenges and opportunities for such collaborative endeavors to enhance equitable partnerships. This qualitative study adopted an interpretative approach involving a thematic analysis of 15 semi-structured interviews with AMR experts conducting research in the region. The study identified several factors influencing research collaborations, such as the multi-dimensional nature of AMR, limited or lack of funds, different AMR research priorities in Asian countries, absence of Asia-centric AMR leadership, lack of trust and, unequal power relationships between researchers, and the negative impact of the COVID-19 pandemic in research collaborations. It also identified some opportunities, such as the willingness of researchers to collaborate, the formation of a few networks, and the prioritization by many academics of the One Health paradigm for framing AMR research. Participants reported that the initiation of stronger cross-discipline and cross-country networks, the development of Asia-centric AMR leadership, flexible research agendas with shared priorities, transparent and transferable funds, and support to enhance research capacity in LMICs could assist in developing more equitable collaborative research in Asia.
抗菌药物耐药性被公认为是对全球卫生安全的重大威胁。世界卫生组织东南亚区域被称为“抗菌药物耐药性出现的全球中心”，因为在亚洲所有世卫组织区域中，该区域出现抗菌药物耐药性的风险最高。因此，需要开展以亚洲为中心、与该区域的实际需求和优先事项相一致的抗菌药物耐药性合作研究。本研究旨在确定并了解此类合作努力在加强公平伙伴关系方面所面临的挑战和机遇。这项定性研究采用了解释性方法，对在该区域开展研究的15位抗菌药物耐药性专家进行了半结构化访谈，并进行了主题分析。该研究确定了影响研究合作的若干因素，例如抗菌药物耐药性的多维度性质、资金有限或缺乏、亚洲国家不同的抗菌药物耐药性研究优先事项、缺乏以亚洲为中心的抗菌药物耐药性领导力、缺乏信任、研究人员之间不平等的权力关系以及新冠疫情对研究合作的负面影响。研究还确定了一些机遇，例如研究人员的合作意愿、一些网络的形成，以及许多学者将“同一健康”范式作为构建抗菌药物耐药性研究的优先事项。参与者报告称，启动更强大的跨学科和跨国网络、培养以亚洲为中心的抗菌药物耐药性领导力、制定具有共同优先事项的灵活研究议程、提供透明且可转移的资金，以及支持加强低收入和中等收入国家的研究能力，有助于在亚洲开展更公平的合作研究。
