3D Lab (Development, Differentiation and Degeneration), Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Int J Mol Sci. 2022 Jun 9;23(12):6449. doi: 10.3390/ijms23126449.
Genetic mosaicism is an intriguing physiological feature of the mammalian brain that generates altered genetic information and provides cellular, and prospectively functional, diversity in a manner similar to that of the immune system. However, both its origin and its physiological significance remain poorly characterized. Most, if not all, cases of somatic mosaicism require prior generation and repair of DNA double strand breaks (DSBs). The relationship between DSB generation, neurogenesis, and early neuronal cell death revealed by our studies in the developing retina provides new perspectives on the different mechanisms that contribute to DNA rearrangements in the developing brain. Here, we speculate on the physiological significance of these findings.
遗传嵌合是哺乳动物大脑的一个有趣的生理特征，它产生改变的遗传信息，并以类似于免疫系统的方式提供细胞和潜在的功能多样性。然而，其起源和生理意义仍未得到很好的描述。如果不是所有的话，大多数体细胞嵌合体都需要预先产生和修复 DNA 双链断裂 (DSB)。我们在发育中的视网膜中进行的研究揭示了 DSB 的产生、神经发生和早期神经元细胞死亡之间的关系，为导致发育中大脑 DNA 重排的不同机制提供了新的视角。在这里，我们推测这些发现的生理意义。
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