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有机量子点:用于癌症治疗和诊断的超小纳米平台。

Organic quantum dots: An ultrasmall nanoplatform for cancer theranostics.

机构信息

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal 576104, Karnataka, India.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India.

出版信息

J Control Release. 2022 Aug;348:798-824. doi: 10.1016/j.jconrel.2022.06.033. Epub 2022 Jun 27.

Abstract

Tumours are the second leading cause of death globally, generating alterations in biological interactions and, as a result, malfunctioning of crucial genetic traits. Technological advancements have made it possible to identify tumours at the cellular level, making transcriptional gene variations and other genetic variables more easily investigated. Standard chemotherapy is seen as a non-specific treatment that has the potential to destroy healthy cells while also causing systemic toxicity in individuals. As a result, developing new technologies has become a pressing necessity. QDs are semiconductor particles with diameters ranging from 2 to 10 nanometers. QDs have grabbed the interest of many researchers due to their unique characteristics, including compact size, large surface area, surface charges, and precise targeting. QD-based drug carriers are well known among the many nanocarriers. Using QDs as a delivery approach enhances solubility, lengthens retention time, and reduces the harmful effects of loaded medicines. Several varieties of quantum dots used in drug administration are discussed in this article, along with their chemical and physical characteristics and manufacturing methods. Furthermore, it discusses the role of QDs in biological, medicinal, and theranostic applications.

摘要

肿瘤是全球第二大致死原因,导致生物相互作用的改变,从而导致关键遗传特征的功能失调。技术的进步使得能够在细胞水平上识别肿瘤,从而更容易研究转录基因变异和其他遗传变量。标准化疗被视为一种非特异性治疗方法,它有可能破坏健康细胞,同时对个体造成全身毒性。因此,开发新技术已成为当务之急。量子点是直径为 2 至 10 纳米的半导体颗粒。由于其独特的特性,包括紧凑的尺寸、大的表面积、表面电荷和精确的靶向性,量子点引起了许多研究人员的兴趣。基于 QD 的药物载体在众多纳米载体中广为人知。将 QD 用作递送方法可提高溶解度、延长保留时间并降低负载药物的有害影响。本文讨论了药物管理中使用的几种量子点,以及它们的化学和物理特性和制造方法。此外,它还讨论了 QD 在生物、医学和治疗应用中的作用。

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