Lesmana Ronny, Zulhendri Felix, Fearnley James, Irsyam Ilham A, Rasyid Renaldi P H N, Abidin Trimurni, Abdulah Rizky, Suwantika Auliya, Paradkar Anant, Budiman Arief S, Pasang Timotius
Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia.
Front Pharmacol. 2022 Jun 8;13:930515. doi: 10.3389/fphar.2022.930515. eCollection 2022.
Propolis is a resinous product collected by bees from plant exudates to protect and maintain hive homeostasis. Propolis has been used therapeutically for centuries as folk medicine. Modern research investigating the diversity of the chemical composition and plant sources, biological activity, extraction processes, analytical methods, and therapeutic properties in clinical settings have been carried out extensively since the 1980s. Due to its antimicrobial, anti-inflammatory, and immuno-modulator properties, propolis appears to be a suitable bioactive component to be incorporated into biomaterials. This review article attempts to analyze the potential application of propolis as a biomaterial component from the available experimental evidence. The efficacy and compabitility of propolis depend upon factors, such as types of extracts and types of biomaterials. Generally, propolis appears to be compatible with hydroxyapatite/calcium phosphate-based biomaterials. Propolis enhances the antimicrobial properties of the resulting composite materials while improving the physicochemical properties. Furthermore, propolis is also compatible with wound/skin dressing biomaterials. Propolis improves the wound healing properties of the biomaterials with no negative effects on the physicochemical properties of the composite biomaterials. However, the effect of propolis on the glass-based biomaterials cannot be generalized. Depending on the concentration, types of extract, and geographical sources of the propolis, the effect on the glass biomaterials can either be an improvement or detrimental in terms of mechanical properties such as compressive strength and shear bond strength. In conclusion, two of the more consistent impacts of propolis across these different types of biomaterials are the enhancement of the antimicrobial and the immune-modulator/anti-inflammatory properties resulting from the combination of propolis and the biomaterials.
蜂胶是蜜蜂从植物分泌物中采集的树脂状产物，用于保护和维持蜂巢的稳态。几个世纪以来，蜂胶一直作为民间药物用于治疗。自20世纪80年代以来，人们广泛开展了现代研究，调查其化学成分和植物来源的多样性、生物活性、提取工艺、分析方法以及临床治疗特性。由于蜂胶具有抗菌、抗炎和免疫调节特性，它似乎是一种适合纳入生物材料的生物活性成分。本文试图根据现有实验证据分析蜂胶作为生物材料成分的潜在应用。蜂胶的功效和相容性取决于提取物类型和生物材料类型等因素。一般来说蜂胶似乎与羟基磷灰石/磷酸钙基生物材料相容。蜂胶可增强所得复合材料的抗菌性能，同时改善其物理化学性能。此外，蜂胶也与伤口/皮肤敷料生物材料相容。蜂胶可改善生物材料的伤口愈合性能，且对复合生物材料的物理化学性能没有负面影响。然而，蜂胶对玻璃基生物材料的影响不能一概而论。根据蜂胶的浓度、提取物类型和地理来源，其对玻璃生物材料的影响在抗压强度和剪切粘结强度等机械性能方面可能是改善也可能是有害的。总之，在这些不同类型的生物材料中，蜂胶较为一致的两个影响是，蜂胶与生物材料结合可增强抗菌性能以及免疫调节/抗炎性能。
