Wu Yu-Hsueh, Jin Ying-Tai, Wu Yang-Che, Yu-Fong Chang Julia, Chiang Chun-Pin, Sun Andy
Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Institute of Oral Medicine, School of Dentistry, National Cheng Kung University, Tainan, Taiwan.
J Dent Sci. 2022 Apr;17(2):935-941. doi: 10.1016/j.jds.2021.11.017. Epub 2021 Dec 9.
BACKGROUND/PURPOSE: Our previous study found that 19.8%, 16.2%, 4.8%, 2.3%, 19.2%, and 12.3% of 884 burning mouth syndrome (BMS) patients have anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity, respectively. This study mainly evaluated the anemia, hematinic deficiencies, and hyperhomocysteinemia in 212 male and 672 female BMS patients.
The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, GPCA levels in 212 male and 672 female BMS patients were measured and compared with the corresponding levels in 106 male and 336 female healthy control subjects, respectively.
We found that 212 male BMS patients had significantly lower mean blood Hb, serum iron, vitamin B12, and folic acid levels and significantly higher mean serum homocysteine levels than 106 male healthy control subjects. Moreover, 672 female BMS patients had significantly lower mean blood Hb and serum iron levels and significantly higher mean serum homocysteine level than 336 female healthy control subjects. In addition, 212 male BMS patients had significantly higher mean blood Hb and serum homocysteine levels, significantly lower mean serum vitamin B12 and folic acid levels, and significantly higher frequencies of folic acid deficiency and hyperhomocysteinemis than 672 female BMS patients.
The male BMS patients do have significantly higher mean blood Hb and serum homocysteine levels, significantly lower mean serum vitamin B12 and folic acid levels, and significantly higher frequencies of folic acid deficiency and hyperhomocysteinemis than the female BMS patients.
背景/目的：我们之前的研究发现，884例灼口综合征（BMS）患者中，分别有19.8%、16.2%、4.8%、2.3%、19.2%和12.3%的患者存在贫血、血清铁、维生素B12和叶酸缺乏、高同型半胱氨酸血症以及血清胃壁细胞抗体（GPCA）阳性。本研究主要评估212例男性和672例女性BMS患者的贫血、造血物质缺乏和高同型半胱氨酸血症情况。
测定212例男性和672例女性BMS患者的血红蛋白（Hb）、血清铁、维生素B12、叶酸、同型半胱氨酸、GPCA水平，并分别与106例男性和336例女性健康对照者的相应水平进行比较。
我们发现，212例男性BMS患者的平均血液Hb、血清铁、维生素B12和叶酸水平显著低于106例男性健康对照者，而平均血清同型半胱氨酸水平显著高于后者。此外，672例女性BMS患者的平均血液Hb和血清铁水平显著低于336例女性健康对照者，平均血清同型半胱氨酸水平显著高于后者。另外，212例男性BMS患者的平均血液Hb和血清同型半胱氨酸水平显著高于672例女性BMS患者，平均血清维生素B12和叶酸水平显著低于后者，叶酸缺乏和高同型半胱氨酸血症的发生率也显著高于后者。
男性BMS患者的平均血液Hb和血清同型半胱氨酸水平显著高于女性BMS患者，平均血清维生素B12和叶酸水平显著低于后者，叶酸缺乏和高同型半胱氨酸血症的发生率也显著高于后者。
