Department of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.
Small. 2022 Jul;18(29):e2201462. doi: 10.1002/smll.202201462. Epub 2022 Jun 27.
Osseous tissue repair has advanced due to the introduction of tissue engineering. The key elements required while engineering new tissues involve scaffolds, cells, and bioactive cues. The macrostructural to the nanostructural framework of such complex tissue has engrossed the intervention of nanotechnology for efficient neo-bone formation. Gold nanoparticles (GNPs) have recently gained interest in bone tissue regeneration due to their multimodal functionality. They are proven to modulate the properties of scaffolds and the osteogenic cells significantly. GNPs also influence different metabolic functions within the body, which directly or indirectly govern the mechanism of bone regeneration. Therefore, this review highlights nanoparticle-mediated osteogenic development, focusing on different aspects of GNPs ranging from scaffold modulation to cellular stimulation. The toxic aspects of gold nanoparticles studied so far are critically explicated, while further insight into the advancements and prospects of these nanoparticles in bone regeneration is also highlighted.
由于组织工程学的引入，骨组织修复得到了发展。在工程新组织时，需要的关键要素包括支架、细胞和生物活性线索。这种复杂组织的宏观结构到纳米结构框架引起了纳米技术的介入，以实现有效的新骨形成。由于具有多种功能，金纳米颗粒（GNPs）最近在骨组织再生中引起了关注。它们被证明可以显著调节支架和成骨细胞的特性。GNPs 还影响体内的不同代谢功能，这些功能直接或间接地控制着骨再生的机制。因此，本综述重点介绍了纳米颗粒介导的成骨发育，聚焦于 GNPs 的不同方面，从支架调节到细胞刺激。本文还批判性地解释了迄今为止研究的金纳米颗粒的毒性方面，同时还强调了这些纳米颗粒在骨再生方面的进展和前景。
