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基于金纳米粒子@铈-四吡啶基联苯共价有机框架的高灵敏便捷适体传感器用于玉米赤霉烯酮的定量测定

Highly sensitive and convenient aptasensor based on Au NPs@Ce-TpBpy COF for quantitative determination of zearalenone.

作者信息

Chen Zhixiong, Yang Meng, Li Ziying, Liao Wenchun, Chen Bengqi, Yang Tong, Hu Rong, Yang Yunhui, Meng Shuang

机构信息

College of Chemistry and Chemical Engineering, Yunnan Normal University Kunming 650500 China

出版信息

RSC Adv. 2022 Jun 13;12(27):17312-17320. doi: 10.1039/d2ra02093a. eCollection 2022 Jun 7.

DOI:10.1039/d2ra02093a
PMID:35765447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9192137/
Abstract

In this work, an aptasensor based on a portable U-disk electrochemical workstation in combination with a screen-printed electrode (SPE) is demonstrated for the quantitative determination of zearalenone (ZEN). The aptamer is immobilized on Au NPs@Ce-TpBpy COF (Covalent organic frameworks), which is modified on the surface of glassy carbon electrode. ZEN specifically binds to ZEN aptamer, which hinders the electron transfer and decreases the catalytic current of Au NPs@Ce-TpBpy COF for the reduction of hydrogen peroxide, measured by chronoamperometry (-). The quantitative detection of ZEN toxin is realized by a decrease of the catalytic current (Δ). Under the optimal experimental conditions, the aptamer sensor exhibited excellent sensitivity, selectivity, reproducibility. A wide linear range of 1 pg mL-10.0 ng mL with a detection limit of 0.389 pg mL (at 3) was obtained. The linear equation is Δ = 0.401 lg  + 1.948 with a correlation coefficient of 0.9906. The recovery is in the range of 93.0-104.7% for the cornflour samples. The proposed method offers a new strategy for the rapid, inexpensive, and real-time detection of ZEN.

摘要

在本研究中，展示了一种基于便携式U盘电化学工作站与丝网印刷电极（SPE）相结合的适体传感器，用于玉米赤霉烯酮（ZEN）的定量测定。适体固定在Au NPs@Ce-TpBpy COF（共价有机框架）上，该材料修饰在玻碳电极表面。ZEN与ZEN适体特异性结合，这会阻碍电子转移并降低Au NPs@Ce-TpBpy COF对过氧化氢还原的催化电流，通过计时电流法（-）测量。通过催化电流的降低（Δ）实现对ZEN毒素的定量检测。在最佳实验条件下，适体传感器表现出优异的灵敏度、选择性和重现性。获得了1 pg mL-10.0 ng mL的宽线性范围，检测限为0.389 pg mL（在3时）。线性方程为Δ = 0.401 lg + 1.948，相关系数为0.9906。玉米粉样品的回收率在93.0-104.7%范围内。所提出的方法为ZEN的快速、廉价和实时检测提供了一种新策略。

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