Sethuraman Sathya, Ramalingam Karthikeyan, Ramani Pratibha, M Kalaiyarasan
Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 May 7;16(5):e59779. doi: 10.7759/cureus.59779. eCollection 2024 May.
Oral cancer is among the highest in the Indian subcontinent. Advanced stages of oral cancer are associated with severe morbidity and higher mortality. Salivary diagnosis is novel and non-invasive. It could be employed on patients even with restricted mouth opening. Hence, an attempt was made to retrieve relevant data regarding this clinically relevant topic. This article has reviewed metal oxide nanoparticles as a biosensor (BS) in salivary diagnosis for oral cancer. Gold, copper oxide, and carbon nanotubes (CNTs) were used in BS applications. A search from the PUBMED database collection (2004 to 2024) was performed to identify the nanoparticle biomarkers and salivary diagnosis in oral cancer. It revealed 30 articles. All the relevant data was extracted and tabulated in this review. We have discussed the relevance of these BS in salivary diagnosis with their corresponding clinical parameters and sensitivity. We hope that this review summarizes the available literature on this topic and incites dedicated research in prompt and early diagnosis of oral cancer, which directly influences the quality of life outcomes in such patients.
口腔癌在印度次大陆的发病率位居前列。口腔癌晚期与严重的发病率和较高的死亡率相关。唾液诊断是一种新型的非侵入性诊断方法。即使是张口受限的患者也可以采用。因此，我们试图检索有关这一临床相关主题的相关数据。本文综述了金属氧化物纳米颗粒作为口腔癌唾液诊断生物传感器的研究。金、氧化铜和碳纳米管被应用于生物传感器。通过检索PUBMED数据库（2004年至2024年）来识别口腔癌中的纳米颗粒生物标志物和唾液诊断。共检索到30篇文章。本综述提取了所有相关数据并制成表格。我们讨论了这些生物传感器在唾液诊断中的相关性及其相应的临床参数和灵敏度。我们希望这篇综述能够总结该主题的现有文献，并激发在口腔癌早期快速诊断方面的专项研究，这直接影响此类患者的生活质量。
