Department of Cardiology, Yue Bei People's Hospital, Shantou University Medical College, Shaoguan 512025, China.
Medical Research Center and Clinical Laboratory Medicine, Yue Bei People's Hospital, Shantou University Medical College, Shaoguan 512025, China.
Dis Markers. 2022 Jun 21;2022:5402507. doi: 10.1155/2022/5402507. eCollection 2022.
Acute aortic dissection (AAD), a serious and fatal cardiovascular disease, is characterized by inflammation that may further aggravate the condition. We evaluated the value of the neutrophil-to-platelet ratio (NPR) in the prognosis of AAD.
We collected records of patients with AAD and clinical data from 2010 to 2020 and followed up on the relevant information for 136 months. The Kaplan-Meier (K-M) survival along with the univariate and multivariate Cox analyses was used to examine the prognostic value of NPR in AAD. In addition, nomograms were constructed by combining NPR, age, Stanford typing, and treatment methods. The accuracy of nomograms was evaluated using calibration plots, and the prediction efficiency of nomograms was evaluated by receiver operating characteristic curve analysis and decision curve analysis (DCA).
The K-M analysis showed that AAD patients with higher NPR exhibited worse prognosis. In addition, different Stanford typing and treatment methods produced varied prognosis results. Univariate and multivariate Cox analyses showed that NPR value, age, classification, and treatment were independent prognostic factors for the overall survival time of patients with AAD. Nomograms constructed by combining NPR, age, Stanford typing, and treatment methods showed good predictive efficacy, and the AUC values for 1-, 3-, and 5-year predicting were 0.82, 0.79, and 0.74, respectively.
Our results suggest that pretreatment NPR can be used as a potential prognostic marker of overall survival time in patients with AAD.
急性主动脉夹层（AAD）是一种严重且致命的心血管疾病，其特征为炎症，这可能会进一步加重病情。我们评估了中性粒细胞与血小板比值（NPR）在 AAD 预后中的价值。
我们收集了 2010 年至 2020 年 AAD 患者的记录和临床数据，并对相关信息进行了 136 个月的随访。采用 Kaplan-Meier（K-M）生存曲线和单因素及多因素 Cox 分析评估 NPR 在 AAD 中的预后价值。此外，通过结合 NPR、年龄、斯坦福分型和治疗方法构建列线图。通过校准图评估列线图的准确性，并通过接收者操作特征曲线分析和决策曲线分析（DCA）评估列线图的预测效率。
K-M 分析表明，NPR 较高的 AAD 患者预后较差。此外，不同的斯坦福分型和治疗方法产生了不同的预后结果。单因素和多因素 Cox 分析表明，NPR 值、年龄、分类和治疗是 AAD 患者总生存时间的独立预后因素。通过结合 NPR、年龄、斯坦福分型和治疗方法构建的列线图显示出良好的预测效果，1、3、5 年预测的 AUC 值分别为 0.82、0.79 和 0.74。
我们的研究结果表明，NPR 可作为 AAD 患者总生存时间的潜在预后标志物。
