Lebar Vojka, Laganà Antonio Simone, Chiantera Vito, Kunič Tina, Lukanović David
Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Unit of Gynecologic Oncology, ARNAS "Civico-Di Cristina-Benfratelli", Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.
J Clin Med. 2022 Jun 30;11(13):3800. doi: 10.3390/jcm11133800.
Researchers have been studying COVID-19 from day one, but not much is known about the impact of COVID-19 on the reproductive system, specifically the female reproductive system. There has been substantial anecdotal and media coverage on the effect of COVID-19 on the female reproductive system and changes in the menstrual cycle, but so far available data are not robust enough to draw firm conclusions about the topic. This article was carried out to present already published studies on the correlation between SARS-CoV-2 infection and menstrual cycle changes. A systematic literature search was conducted on the Medline, Scopus, and Cochrane Library databases in accordance with the PRISMA guidelines. Three studies were finally included in the review. The findings of the studies indicate changes in menstrual volume and changes in menstrual cycle length as consequences of SARS-CoV-2 infection; the latter was also the most common menstrual irregularity reported by the included studies. Women have mainly reported decreased menstrual volume and a prolonged cycle. The findings also indicate that the severity of COVID-19 does not play a role in menstrual cycle changes. However, the research on this topic is still too scarce to draw definitive conclusions, and there is a need for further research. The relevant conclusions, which could be drawn only from a well-constructed study, would have a major effect on defining the impact of SARS-CoV-2 infection on the menstrual cycle.
从第一天起，研究人员就一直在研究新冠病毒，但对于新冠病毒对生殖系统，特别是女性生殖系统的影响，我们所知甚少。关于新冠病毒对女性生殖系统的影响以及月经周期变化，已有大量传闻和媒体报道，但到目前为止，现有数据还不够充分，无法就该主题得出确凿结论。本文旨在介绍已发表的关于新冠病毒感染与月经周期变化之间相关性的研究。根据PRISMA指南，对Medline、Scopus和Cochrane图书馆数据库进行了系统的文献检索。最终有三项研究被纳入综述。这些研究的结果表明，新冠病毒感染会导致月经量变化和月经周期长度改变；后者也是纳入研究中报告的最常见的月经不规律情况。女性主要报告月经量减少和周期延长。研究结果还表明，新冠病毒感染的严重程度在月经周期变化中不起作用。然而，关于这个主题的研究仍然太少，无法得出明确结论，因此有必要进行进一步研究。只有通过精心构建的研究才能得出的相关结论，将对确定新冠病毒感染对月经周期的影响产生重大作用。
