Department of Pharmacognosy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland.
Nutrients. 2022 Jun 21;14(13):2560. doi: 10.3390/nu14132560.
Imitating the human digestive system as closely as possible is the goal of modern science. The main reason is to find an alternative to expensive, risky and time-consuming clinical trials. Of particular interest are models that simulate the gut microbiome. This paper aims to characterize the human gut microbiome, highlight the importance of its contribution to disease, and present in vitro models that allow studying the microbiome outside the human body but under near-natural conditions. A review of studies using models SHIME, SIMGI, TIM-2, ECSIM, EnteroMix, and PolyfermS will provide an overview of the options available and the choice of a model that suits the researcher's expectations with advantages and disadvantages.
尽可能逼真地模拟人体消化系统是现代科学的目标。其主要原因是寻找一种替代昂贵、风险大且耗时的临床试验的方法。特别引人关注的是能够模拟肠道微生物组的模型。本文旨在描述人体肠道微生物组，强调其对疾病的重要贡献，并介绍能够在体外接近自然条件下研究微生物组的模型。对使用 SHIME、SIMGI、TIM-2、ECSIM、EnteroMix 和 PolyfermS 模型的研究进行综述，将提供可用选项的概述，并选择适合研究人员期望的模型，同时权衡其优缺点。
