Department of Agricultural, Forestry and Food Science, University of Torino, 10095 Torino, Italy.
Department of Medical Sciences, University of Torino, 10126 Torino, Italy.
Nutrients. 2022 Jun 21;14(13):2569. doi: 10.3390/nu14132569.
The metabolic benefits of time-restricted eating (TRE) in humans are statistically significant but not clinically relevant. Few data are available about the effects of TRE on the gut microbiota. We compared the effects of a TRE regimen (<12 h feeding; n = 25) with a time-unrestricted (TUE) regimen (>12 h feeding; n = 24), on the clinical and dietary variables and gut-microbiota composition in patients with obesity, who were subjected for 12 weeks to the same caloric restriction. Median weight loss was 4.0 kg and 2.2 kg in the TRE and TUE groups, respectively, with a between-group borderline difference (p = 0.049). No significant between-group difference was found in other dietary, anthropometric, or laboratory variables. There were no substantial between-group differences in alpha and beta diversity or gut-microbiota composition. The TRE group showed a significant increase in the frequency of Lachnospiraceae, Parasutterella, and Romboutsia at the study’s end. A TRE regimen induced small changes both in metabolic/dietary variables and in the gut-microbiota composition, with respect to the TUE. The microbial changes we have found were of uncertain clinical significance.
限时进食（TRE）对人体的代谢益处具有统计学意义，但无临床相关性。关于 TRE 对肠道微生物群的影响的数据很少。我们比较了限时进食（<12 小时喂养；n = 25）与不限时进食（>12 小时喂养；n = 24）方案对肥胖患者的临床和饮食变量以及肠道微生物群组成的影响，这些患者在 12 周内接受相同的热量限制。在 TRE 和 TUE 组中，体重中位数分别减轻了 4.0 公斤和 2.2 公斤，两组之间存在边缘差异（p = 0.049）。在其他饮食、人体测量和实验室变量方面，两组间无显著差异。α多样性和β多样性或肠道微生物群组成在两组间没有实质性差异。TRE 组在研究结束时，lachnospiraceae、Parasutterella 和 Romboutsia 的频率显著增加。与 TUE 相比，TRE 方案在代谢/饮食变量和肠道微生物群组成方面引起了较小的变化。我们发现的微生物变化的临床意义尚不确定。
Zotero 插件
