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限时饮食方案对体重减轻的影响是由肠道微生物群介导的。

Effect of time-restricted eating regimen on weight loss is mediated by gut microbiome.

作者信息

Huang Chensihan, Liu Deying, Yang Shunyu, Huang Yan, Wei Xueyun, Zhang Peizhen, Lin Jiayang, Xu Bingyan, Liu Yating, Guo Dan, Li Yafeng, Li Jin, Zhang Huijie

机构信息

Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China.

Department of Nutrition, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China.

出版信息

iScience. 2024 Jun 6;27(7):110202. doi: 10.1016/j.isci.2024.110202. eCollection 2024 Jul 19.

DOI:10.1016/j.isci.2024.110202
PMID:38993674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11238135/
Abstract

Time-restricted eating (TRE) is a promising obesity management strategy, but weight-loss efficacy varies among participants, and the underlying mechanism is unclear. The study aimed to investigate the role of gut microbiota in weight-loss response during long-term TRE intervention. We analyzed data from 51 obese adults in a 12-month TRE program, categorizing them into distinct weight loss groups (DG) and moderate weight loss groups (MG) based on their TRE responses. Shotgun metagenomic sequencing analysis revealed a significant increase in species closely associated with weight loss effectiveness and metabolic parameter changes in the DG group. Pathways related to fatty acid biosynthesis, glycogen biosynthesis, and nucleotide metabolism were reduced in the DG group and enhanced in the MG group. Next, we identified nine specific species at baseline that contributed better responses to TRE intervention and significant weight loss. Collectively, gut microbiota contributes to responsiveness heterogeneity in TRE and can predict weight-loss effectiveness.

摘要

限时进食（TRE）是一种很有前景的肥胖管理策略，但参与者的减肥效果各不相同，其潜在机制尚不清楚。该研究旨在调查肠道微生物群在长期TRE干预期间减肥反应中的作用。我们分析了51名肥胖成年人参加为期12个月的TRE项目的数据，根据他们的TRE反应将他们分为明显减重组（DG）和中度减重组（MG）。鸟枪法宏基因组测序分析表明，DG组中与减肥效果和代谢参数变化密切相关的物种显著增加。DG组中与脂肪酸生物合成、糖原生物合成和核苷酸代谢相关的途径减少，而MG组中则增强。接下来，我们在基线时确定了9种特定物种，它们对TRE干预和显著减重有更好的反应。总体而言，肠道微生物群导致了TRE反应的异质性，并可以预测减肥效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/f8490330e16d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/010b6c0dbf14/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/e9ecf49b703a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/1b6b383e470d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/8f12088cbabd/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/e6d9e674b18e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/03cfe6f8bcb9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/f8490330e16d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/010b6c0dbf14/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/e9ecf49b703a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/1b6b383e470d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/8f12088cbabd/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/e6d9e674b18e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/03cfe6f8bcb9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb70/11238135/f8490330e16d/gr6.jpg

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