Djeunang Dongho Ghyslaine Bruna, Venturi Giulietta, Fortuna Claudia, Paganotti Giacomo Maria, Severini Carlo, L'Episcopia Mariangela, Tsapi Armand Tiotsia, Benedetti Eleonora, Marsili Giulia, Amendola Antonello, Rezza Giovanni, Sobze Martin Sanou, Russo Gianluca
Laboratory of Immunogenetics, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Access Microbiol. 2022 Apr 29;4(4):000340. doi: 10.1099/acmi.0.000340. eCollection 2022.
We report the molecular evidence of dengue virus (DENV) and chikungunya virus (CHIKV) infection in symptomatic individuals in Cameroon and Gabon, respectively. Arthropod-borne viruses (arboviruses) are distributed in the tropical or subtropical regions, with DENV having the highest burden. The morbidity and mortality related to arboviral diseases raise the concern of timely and efficient surveillance and care. Our aim was to assess the circulation of arboviruses [DENV, CHIKV, Zika virus (ZIKV)] among febrile patients in Dschang (West Cameroon) and Kyé-ossi (South Cameroon, border with Gabon and Equatorial Guinea). Dried blood spots were collected from 601 consenting febrile patients, and 194 spp.-negative samples were tested for the molecular detection of cases of DENV, CHIKV and ZIKV infection. Overall, no case of ZIKV infection was found, whereas one case of DENV infection and one case of CHIKV infection were detected in Dschang and Kyé-ossi, respectively, with the CHIKV-infected patient being resident in Gabon. Our findings suggest the need to establish an active surveillance of arbovirus transmission in Cameroon and bordering countries.
我们分别报告了喀麦隆和加蓬有症状个体感染登革病毒（DENV）和基孔肯雅病毒（CHIKV）的分子证据。虫媒病毒分布于热带或亚热带地区，其中登革病毒造成的负担最重。虫媒病毒病相关的发病率和死亡率引发了对及时有效监测与护理的关注。我们的目的是评估在喀麦隆西部的贾格和喀麦隆南部与加蓬及赤道几内亚接壤的凯奥西发热患者中虫媒病毒（登革病毒、基孔肯雅病毒、寨卡病毒）的传播情况。从601名同意参与的发热患者中采集了干血斑，并对194份疟原虫检测阴性的样本进行了登革病毒、基孔肯雅病毒和寨卡病毒感染病例的分子检测。总体而言，未发现寨卡病毒感染病例，而在贾格和凯奥西分别检测到1例登革病毒感染病例和1例基孔肯雅病毒感染病例，感染基孔肯雅病毒的患者居住在加蓬。我们的研究结果表明，有必要在喀麦隆及其周边国家建立虫媒病毒传播的主动监测机制。
