Nantes Université, Institut National de la Santé et de la Recherche Médicale UMR1307, Centre National de la Recherche Scientifique UMR6075, Université d'Angers, Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers CRCI2NA, Nantes, France;
LabEx Immunotherapy, Graft, Oncology, Nantes, France.
J Immunol. 2022 Jul 15;209(2):217-225. doi: 10.4049/jimmunol.2200105.
Innate-like T cells display characteristics of both innate lymphoid cells (ILCs) and mainstream αβ T cells, leading to overlapping functions of innate-like T cells with both subsets. In this review, we show that although innate-like T cells are probably present in all vertebrates, their main characteristics are much better known in amphibians and mammals. Innate-like T cells encompass both γδ and αβ T cells. In mammals, γδ TCRs likely coevolved with molecules of the butyrophilin family they interact with, whereas the semi-invariant TCRs of iNKT and mucosal-associated invariant T cells are evolutionarily locked with their restricting MH1b molecules, CD1d and MR1, respectively. The strong conservation of the Ag recognition systems of innate-like T cell subsets despite similar effector potentialities supports that each one fulfills nonredundant roles related to their Ag specificity.
先天样 T 细胞兼具先天淋巴细胞 (ILCs) 和主流 αβ T 细胞的特征，导致先天样 T 细胞与这两个亚群的功能重叠。在这篇综述中，我们表明，尽管先天样 T 细胞可能存在于所有脊椎动物中，但它们的主要特征在两栖动物和哺乳动物中更为人所知。先天样 T 细胞包括 γδ 和 αβ T 细胞。在哺乳动物中，γδ TCR 可能与它们相互作用的丁酰膦蛋白家族的分子共同进化，而 iNKT 和黏膜相关不变 T 细胞的半不变 TCR 分别与它们的限制 MH1b 分子 CD1d 和 MR1 锁定进化。先天样 T 细胞亚群的 Ag 识别系统尽管具有相似的效应潜能，但仍保持着强烈的保守性，这支持了它们各自履行与其 Ag 特异性相关的非冗余作用。
