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小家鼠和西班牙小鼠种间杂交中X连锁标记基因的分离畸变。

Segregation distortion of X-linked marker genes in interspecific crosses between Mus musculus and M. spretus.

作者信息

Biddle F G

出版信息

Genome. 1987 Apr;29(2):389-92. doi: 10.1139/g87-067.

DOI:10.1139/g87-067
PMID:3582977
Abstract

An interspecific cross was made between females of the C3H/HeHa.Pgk-1 a inbred laboratory strain of Mus musculus and males of the separate species Mus spretus. The F1 males are sterile but the F1 females are fertile and they were backcrossed to both C3H and spretus males. Evidence is presented from the segregation of X-linked marker genes that the interspecific F1 female has a genetically deleterious effect on the C3H X chromosome that is expressed as a male-lethal effect with the spretus Y chromosome but not with the musculus Y chromosome of C3H.

摘要

在小家鼠的近交实验室品系C3H/HeHa.Pgk-1 a的雌性与不同物种西班牙小鼠的雄性之间进行了种间杂交。F1雄性不育，但F1雌性可育，并且它们与C3H和西班牙小鼠的雄性都进行了回交。从X连锁标记基因的分离情况来看，种间F1雌性对C3H X染色体具有遗传有害效应，在与西班牙小鼠的Y染色体结合时表现为雄性致死效应，但与C3H的小家鼠Y染色体结合时则不会。

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