Emanuelli G, Lanzio M, Anfossi T, Romano S, Anfossi G, Calcamuggi G
Gerontology. 1986;32(6):308-16. doi: 10.1159/000212809.
Polymorphonuclear leukocytes (PMNs) represent an important defensive mechanism against infectious agents. Some of their functions are impaired in old people, with a decreased effectiveness of nonspecific immunity. In vitro PMN phagocytic activity was studied with different techniques on 74 healthy subjects (20-82.5 years; 40 males, 34 females). Serum-mediated ingestion resulted to be impaired with age with a lower ratio of active PMNs and a lower activity of phagocytosing cells. The behavior of these parameters was age-related, without significant difference between males and females; the decline was found to be a continuous phenomenon with no threshold age. Serum-independent ingestion had very low values and was not impaired with aging. The present data can represent a further explanation for the finding of a higher incidence and mortality of bacterial diseases in elderly population.
多形核白细胞（PMNs）是抵御感染因子的重要防御机制。其一些功能在老年人中受损，非特异性免疫的有效性降低。采用不同技术对74名健康受试者（年龄20 - 82.5岁；男性40名，女性34名）的体外PMN吞噬活性进行了研究。血清介导的摄取随年龄增长而受损，活性PMN比例降低，吞噬细胞活性降低。这些参数的变化与年龄相关，男女之间无显著差异；发现这种下降是一个持续的现象，没有阈值年龄。非血清依赖性摄取的值非常低，且不会随年龄增长而受损。目前的数据可以进一步解释老年人群中细菌性疾病发病率和死亡率较高这一现象。
