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将人类疱疹病毒8型相关的卡波西肉瘤误诊为药物不良反应性皮疹。

Misdiagnosis of Human Herpes Virus-8-Associated Kaposi's Sarcoma as Adverse Drug Eruptions.

作者信息

Kim Tae Hyung, Wee Syeo Young, Jeong Hyun Gyo, Choi Hwan Jun

机构信息

Department of Plastic and Reconstructive Surgery, Soonchunhyang University Gumi Hospital, Soonchunhyang University College of Medicine, Gumi, Republic of Korea.

Department of Plastic and Reconstructive Surgery, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.

出版信息

Arch Plast Surg. 2022 May 27;49(3):457-461. doi: 10.1055/s-0042-1748664. eCollection 2022 May.

DOI:10.1055/s-0042-1748664
PMID:35832152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9142249/
Abstract

Kaposi's sarcoma (KS) is a cancer that causes patches of abnormal tissue to grow under the skin. It also occurs in the immunosuppressive population. KS is currently believed to be caused by infection with human herpes virus-8 (HHV-8) in non-human immunodeficiency virus patient. A 79-year-old female visited the outpatient clinic presenting with increasing number and size of palpable masses on both upper and lower extremities. She was first diagnosed as drug-erupted dermatitis and stopped her medications, but the symptoms got worse. We did partial biopsy, and KS with HHV-8 was diagnosed histopathologically. She planned to undergo further evaluations and proper treatments. This rare case suggests the need to consider a classic type of KS in the differential diagnosis of specific dermatologic symptoms such as macular, nodular, and darkish patches of upper or lower extremities in elderly patients. It is believed that this case helps to strengthen awareness of this rare disease.

摘要

卡波西肉瘤(KS)是一种会导致皮肤下生长出异常组织斑块的癌症。它也会出现在免疫抑制人群中。目前认为,在非人类免疫缺陷病毒患者中,KS是由人类疱疹病毒8型(HHV-8)感染引起的。一名79岁女性前往门诊就诊,其上下肢可触及肿块的数量和大小均不断增加。她最初被诊断为药物性皮疹性皮炎并停用了药物,但症状却加重了。我们进行了部分活检,经组织病理学诊断为伴有HHV-8的KS。她计划接受进一步评估和适当治疗。这一罕见病例表明,在对老年患者上下肢出现的斑疹、结节及深色斑块等特定皮肤症状进行鉴别诊断时,有必要考虑经典型KS。据信,该病例有助于增强对这种罕见疾病的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/9142249/3fc4bef7c2f3/10-1055-s-0042-1748664-i21253-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/9142249/4f984232a4d9/10-1055-s-0042-1748664-i21253-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/9142249/9f4e854038ba/10-1055-s-0042-1748664-i21253-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/9142249/be762028713d/10-1055-s-0042-1748664-i21253-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/9142249/3fc4bef7c2f3/10-1055-s-0042-1748664-i21253-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/9142249/4f984232a4d9/10-1055-s-0042-1748664-i21253-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/9142249/9f4e854038ba/10-1055-s-0042-1748664-i21253-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/9142249/be762028713d/10-1055-s-0042-1748664-i21253-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/9142249/3fc4bef7c2f3/10-1055-s-0042-1748664-i21253-4.jpg

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本文引用的文献

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Efficacy of chemotherapeutics in classic and non-classic Kaposi sarcoma: A single-center retrospective real-world data.经典型和非经典型卡波西肉瘤中化疗药物的疗效:单中心回顾性真实世界数据。
Bosn J Basic Med Sci. 2021 Dec 1;21(6):746-751. doi: 10.17305/bjbms.2020.5329.
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Navigating the heterogeneous landscape of pediatric Kaposi sarcoma.
探讨儿科卡波西肉瘤的异质性景观。
Cancer Metastasis Rev. 2019 Dec;38(4):749-758. doi: 10.1007/s10555-019-09823-3.
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Diagnosis and treatment of Kaposi's sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC).卡波西肉瘤的诊断和治疗:基于欧洲共识的跨学科指南(EDF/EADO/EORTC)。
Eur J Cancer. 2019 Jun;114:117-127. doi: 10.1016/j.ejca.2018.12.036. Epub 2019 May 13.
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AIDS-Related Kaposi Sarcoma, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.艾滋病相关卡波西肉瘤,版本 2.2019,NCCN 肿瘤学临床实践指南。
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