Chang Xingyu, Kang Yuchen, Yang Yuxuan, Chen Yajie, Shen Yanyu, Jiang Chenjun, Shen Yi
The First Clinical Medical College, Lanzhou University, Lanzhou, People's Republic of China.
The Second Clinical Medical College, Lanzhou University, Lanzhou, People's Republic of China.
J Inflamm Res. 2022 Jul 11;15:3859-3871. doi: 10.2147/JIR.S368501. eCollection 2022.
Osteoarthritis (OA) is one of the most common chronic joint diseases and is gradually becoming the main cause of disability and joint pain in the elderly worldwide. Pyroptosis is a regulated programmed cell death triggered by inflammasomes. It leads to cell swelling, lysis, and bioactive molecule secretion. Studies found that the damaged chondrocytes in OA joints had morphological characteristics of pyroptosis, and the cytokines associated with pyroptosis in synovial fluid increased, indicating that pyroptosis may have certain impacts on the pathological progression of OA. This review briefly summarizes the molecular mechanisms of pyroptosis and the epidemiology and pathogenesis of OA. Furthermore, we discussed the role of pyroptosis in articular cartilage and synovium during OA and reviewed the progress of pyroptosis-related molecules in the targeted therapy of OA joints, hoping to provide feasible directions for the diversified treatment of OA.
骨关节炎（OA）是最常见的慢性关节疾病之一，并且正逐渐成为全球老年人残疾和关节疼痛的主要原因。细胞焦亡是由炎性小体触发的一种程序性细胞死亡。它导致细胞肿胀、裂解和生物活性分子分泌。研究发现，OA关节中受损的软骨细胞具有细胞焦亡的形态学特征，并且滑液中与细胞焦亡相关的细胞因子增加，这表明细胞焦亡可能对OA的病理进展有一定影响。本综述简要总结了细胞焦亡的分子机制以及OA的流行病学和发病机制。此外，我们讨论了细胞焦亡在OA期间关节软骨和滑膜中的作用，并综述了细胞焦亡相关分子在OA关节靶向治疗中的进展，希望为OA的多样化治疗提供可行的方向。
