Akhavanallaf Azadeh, Fayad Hadi, Salimi Yazdan, Aly Antar, Kharita Hassan, Al Naemi Huda, Zaidi Habib
Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland.
Hamad Medical Corporation, Doha, Qatar.
Digit Health. 2022 Jul 11;8:20552076221111941. doi: 10.1177/20552076221111941. eCollection 2022 Jan-Dec.
The prevalent availability of high-performance computing coupled with validated computerized simulation platforms as open-source packages have motivated progress in the development of realistic anthropomorphic computational models of the human anatomy. The main application of these advanced tools focused on imaging physics and computational internal/external radiation dosimetry research. This paper provides an updated review of state-of-the-art developments and recent advances in the design of sophisticated computational models of the human anatomy with a particular focus on their use in radiation dosimetry calculations. The consolidation of flexible and realistic computational models with biological data and accurate radiation transport modeling tools enables the capability to produce dosimetric data reflecting actual setup in clinical setting. These simulation methodologies and results are helpful resources for the medical physics and medical imaging communities and are expected to impact the fields of medical imaging and dosimetry calculations profoundly.
高性能计算的广泛可用性，以及作为开源软件包的经过验证的计算机模拟平台，推动了逼真的人体解剖学拟人计算模型开发的进展。这些先进工具的主要应用集中在成像物理和计算内部/外部辐射剂量学研究。本文对人体解剖学复杂计算模型设计的最新进展和近期成果进行了更新回顾，特别关注其在辐射剂量学计算中的应用。将灵活逼真的计算模型与生物数据及精确的辐射传输建模工具相结合，能够生成反映临床实际设置的剂量学数据。这些模拟方法和结果对医学物理和医学成像领域是有益的资源，预计将对医学成像和剂量学计算领域产生深远影响。
