Pamukkale Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı, 20160 Kınıklı, Denizli, Türkiye.
Jt Dis Relat Surg. 2022;33(2):479-483. doi: 10.52312/jdrs.2022.719. Epub 2022 Jul 6.
The use of animals in research has increasingly continued, although there are serious concerns about appropriate methodology, moral issues and translation to clinical practice. The aim of the present article is to review the insufficiency of statements in ethical approvals to obtain animal welfare in real life practices and to draw attention to the need for an additional evidence-based audit system. In many countries, local Animal Ethics Committees are established to ensure that animals are treated in accordance with 3Rs (Replace, Reduce, Refine) principles. Although the ethical approval certificate which is taken before the start of research is considered as the proof of animal welfare, footages released from all over the world reveal the maltreatment. However, due to the scientific resource provided by animal models, it does not seem possible to expect animal experiments to be terminated in the near future. Addition of previously suggested welfare section to methods of study or including the ethical approval certificate does not seem to be sufficient practices to guarantee the animal welfare, since they are not based on audited evidence. The welfare certificate, in which the welfare is supervised by independent auditors, would serve as a proof of both the wellbeing of subjects and consequently the scientific reliability of data. Application of review and publication priority for the animal researches which have the welfare certificate in addition to the ethical approval would encourage the researchers to obtain this certificate. The achievement of worldwide consensus about content, requirements, and application methods of the welfare certificate should be in the scope of scientists in the near future to reach the more humane and more qualified animal experiments.
尽管人们对适当的方法、道德问题和转化为临床实践存在严重担忧，但动物在研究中的使用仍在不断增加。本文旨在回顾伦理批准中存在的不足，以确保在实际生活实践中获得动物福利，并提请注意需要建立额外的基于证据的审核制度。在许多国家，都设立了地方动物伦理委员会，以确保动物按照 3R（替代、减少、优化）原则得到对待。虽然在研究开始前获得的伦理批准证书被认为是动物福利的证明，但来自世界各地的视频揭示了虐待动物的现象。然而，由于动物模型提供了科学资源，似乎不可能期望在不久的将来终止动物实验。将之前建议的福利部分纳入研究方法或包括伦理批准证书，似乎不足以保证动物福利，因为它们不是基于审核证据。福利证书由独立审计员监督福利，可以作为证明实验对象健康状况以及数据科学可靠性的依据。对于那些除了伦理批准外还获得了福利证书的动物研究，应该进行审查和优先发表，这将鼓励研究人员获得该证书。在不久的将来，科学家们应该就福利证书的内容、要求和应用方法达成全球共识，以实现更人道、更有质量的动物实验。
