Scientific Research and Teaching Department, Public Health Clinical Center of Chengdu, 377 Jingming Road, Jinjiang District, Chengdu, Sichuan, 610061, China.
Scientific Research and Teaching Department, Public Health Clinical Center of Chengdu, 377 Jingming Road, Jinjiang District, Chengdu, Sichuan, 610061, China.
Eur J Med Chem. 2022 Oct 5;240:114613. doi: 10.1016/j.ejmech.2022.114613. Epub 2022 Jul 16.
Metabolic reprogramming is now considered as one of hallmark of tumor cells and provides them with a selective survival/growth advantage to resist harsh micro-environmental stress. Fatty acid (FA) metabolism of tumor cells supports the biosynthetic needs and provides fuel sources for energy supply. Since FA metabolic reprogramming is a critical link in tumor metabolism, its various roles in tumors have attracted increasing interest. Herein, we review the mechanisms through which cancer cells rewire their FA metabolism with a focus on the pathway of FA metabolism and its targeting drug development. The failure and successful cases of targeting tumor FA metabolism are expected to bypass the metabolic vulnerability and improve the efficacy of targeted therapy.
代谢重编程现在被认为是肿瘤细胞的标志之一，为它们提供了选择性的生存/生长优势，以抵抗恶劣的微环境压力。肿瘤细胞的脂肪酸 (FA) 代谢为生物合成需求提供支持，并为能量供应提供燃料来源。由于 FA 代谢重编程是肿瘤代谢中的关键环节，因此其在肿瘤中的各种作用引起了越来越多的关注。本文综述了癌细胞重新构建 FA 代谢的机制，重点介绍了 FA 代谢途径及其靶向药物开发。靶向肿瘤 FA 代谢的失败和成功案例有望绕过代谢脆弱性，提高靶向治疗的疗效。
