[具体基因名称]的变体可能与二甲双胍反应不佳有关。 （由于原文“Variants of ”中缺少具体基因名称，所以翻译中用“[具体基因名称]”表示缺失部分）
Variants of may be Linked to Poor Response to Metformin.
作者信息
Paz-Pacheco Elizabeth, Nevado Jose B, Cutiongco-de la Paz Eva Maria C, Jasul Gabriel V, Aman Aimee Yvonne Criselle L, Ribaya Elizabeth Laurize A, Francisco Mark David G, Guanzon Ma Luz Vicenta V, Uyking-Naranjo May L, Añonuevo-Cruz Ma Cecille S, Maningat Maria Patricia Deanna D, Jaring Cristina V, Nacpil-Dominguez Paulette D, Pala-Mohamad Aniza B, Canto Abigail U, Quisumbing John Paul M, Lat Annabelle Marie M, Bernardo Diane Carla C, Mansibang Noemie Marie M, Calpito Karell Jo Angelique C, Ribaya Vincent Sean D, Ferrer Julius Patrick Y, Biwang Jessica H, Melegrito Jodelyn B, Deguit Christian Deo T, Panerio Carlos Emmanuel G
机构信息
Division of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Institutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
出版信息
J Endocr Soc. 2022 Jun 29;6(8):bvac092. doi: 10.1210/jendso/bvac092. eCollection 2022 Aug 1.
PURPOSE
A study among Filipinos revealed that only 15% of patients with diabetes achieved glycemic control, and poor response to metformin could be one of the possible reasons. Recent studies demonstrate how genetic variations influence response to metformin. Hence, the present study aimed to determine genetic variants associated with poor response to metformin.
METHODS
Using a candidate variant approach, 195 adult Filipino participants with newly diagnosed type 2 diabetes mellitus (T2DM) were enrolled in a case-control study. Genomic DNA from blood samples were collected. Allelic and genotypic associations of variants with poor response to metformin were determined using exact statistical methods.
RESULTS
Several polymorphisms were nominally associated with poor response to metformin ( < 0.05). The most notable is the association of multiple variants in the gene-rs2425911, rs3092412, and rs2425904-with common additive genetic mode of inheritance. Other variants that have possible associations with poor drug response include rs340874 (), rs815815 (), rs1333049 (), rs2010963 (), rs1535435 and rs9494266 (), rs11128347 (), rs1805081 (), and rs13266634 ().
CONCLUSION
In Filipinos, a trend for the association for several variants was noted, with further observation that several mechanisms may be involved. The results may serve as pilot data for further validation of candidate variants for T2DM pharmacotherapy.
目的
一项针对菲律宾人的研究表明，只有15%的糖尿病患者实现了血糖控制，对二甲双胍反应不佳可能是其中一个原因。最近的研究表明了基因变异如何影响对二甲双胍的反应。因此，本研究旨在确定与二甲双胍反应不佳相关的基因变异。
方法
采用候选变异方法，195名新诊断为2型糖尿病（T2DM）的成年菲律宾参与者被纳入一项病例对照研究。收集血样中的基因组DNA。使用精确统计方法确定变异与二甲双胍反应不佳的等位基因和基因型关联。
结果
有几种多态性与二甲双胍反应不佳存在名义上的关联（P<0.05）。最显著的是基因rs2425911、rs3092412和rs2425904中的多个变异与常见的加性遗传模式相关。其他可能与药物反应不佳相关的变异包括rs340874（P）、rs815815（P）、rs1333049（P）、rs2010963（P）、rs1535435和rs9494266（P）、rs11128347（P）、rs1805081（P）以及rs13266634（P）。
结论
在菲律宾人中，注意到几种变异存在关联趋势，进一步观察发现可能涉及多种机制。这些结果可作为T2DM药物治疗候选变异进一步验证的先导数据。
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