Macleod R I, Welbury R R, Soames J V
J R Soc Med. 1987 Apr;80(4):207-9. doi: 10.1177/014107688708000405.
A histological study of 21 teeth from 9 patients who had received cytotoxic chemotherapy for malignant disease showed increased prominence of incremental lines in the dentine. The number and distribution of these lines corresponded to periods of intravenous therapy and vincristine appeared to be the most likely cause. This effect was probably due to temporary disturbance of microtubular function in the odontoblasts resulting in decreased secretion of collagenous dentine matrix. Calcification appeared to be unaffected.
对9例因恶性疾病接受细胞毒性化疗患者的21颗牙齿进行的组织学研究显示，牙本质中生长线的突出度增加。这些线的数量和分布与静脉治疗时期相对应，长春新碱似乎是最可能的原因。这种效应可能是由于成牙本质细胞中微管功能的暂时紊乱，导致胶原牙本质基质分泌减少。钙化似乎未受影响。
