幽门弯曲菌与人体免疫防御机制的相互作用。
Interaction of Campylobacter pyloridis with human immune defence mechanisms.
作者信息
Pruul H, Lee P C, Goodwin C S, McDonald P J
出版信息
J Med Microbiol. 1987 May;23(3):233-8. doi: 10.1099/00222615-23-3-233.
PMID:3585959
Abstract
The in-vitro susceptibility to host immune defence mechanisms of Campylobacter pyloridis was investigated. C. pyloridis was sensitive to antibody-dependent complement-mediated bactericidal activity of serum. The bacteria were phagocytosed and efficiently killed by polymorphonuclear neutrophils in the presence of serum opsonins. Serum opsonin depletion studies indicated that an intact classical complement pathway was required for optimal phagocytic killing.
摘要
研究了幽门弯曲菌对宿主免疫防御机制的体外敏感性。幽门弯曲菌对血清中抗体依赖的补体介导的杀菌活性敏感。在血清调理素存在的情况下，多形核中性粒细胞可吞噬并有效杀死这些细菌。血清调理素耗竭研究表明，完整的经典补体途径是最佳吞噬杀伤所必需的。
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