Grenda Tomasz, Grenda Anna, Domaradzki Piotr, Krawczyk Paweł, Kwiatek Krzysztof
Department of Hygiene of Animal Feeding Stuffs, National Veterinary Research Institute, Partyzantow 57, 24-100 Pulawy, Poland.
Department of Pneumonology, Oncology and Allergology, Medical University in Lublin, Jaczewskiego 8, 20-950 Lublin, Poland.
Curr Issues Mol Biol. 2022 Jul 7;44(7):3118-3130. doi: 10.3390/cimb44070215.
spp. is a large genus of obligate anaerobes and is an extremely heterogeneous group of bacteria that can be classified into 19 clusters. Genetic analyses based on the next-generation sequencing of 16S rRNA genes and metagenome analyses conducted on human feces, mucosal biopsies, and luminal content have shown that the three main groups of strict extremophile anaerobes present in the intestines are cluster IV (also known as the group), cluster XIVa (also known as the group) and . In addition to the mentioned clusters, some strains are also considered beneficial for human health. Moreover, this bacterium has been widely used as a probiotic in Asia (particularly in Japan, Korea, and China). The mentioned commensal Clostridia are involved in the regulation and maintenance of all intestinal functions. In the literature, the development processes of new therapies are described based on commensal Clostridia activity. In addition, some Clostridia are associated with pathogenic processes. Some strains detected in stool samples are involved in botulism cases and have also been implicated in severe diseases such as infant botulism and necrotizing enterocolitis in preterm neonates. The aim of this study is to review reports on the possibility of using strains as probiotics, consider their positive impact on human health, and identify the risks associated with the expression of their pathogenic properties.
梭菌属是专性厌氧菌的一个大属，是一类极其多样的细菌，可分为19个簇。基于16S rRNA基因的下一代测序进行的遗传分析以及对人类粪便、黏膜活检和肠腔内容物进行的宏基因组分析表明，肠道中存在的三类主要严格嗜极端厌氧菌是IV簇（也称为XXIV组）、XIVa簇（也称为XIV组）和XXI簇。除了上述簇外，一些梭菌菌株也被认为对人类健康有益。此外，这种细菌在亚洲（特别是在日本、韩国和中国）已被广泛用作益生菌。上述共生梭菌参与所有肠道功能的调节和维持。在文献中，基于共生梭菌活性描述了新疗法的开发过程。此外，一些梭菌与致病过程有关。在粪便样本中检测到的一些梭菌菌株与肉毒中毒病例有关，也与早产儿的婴儿肉毒中毒和坏死性小肠结肠炎等严重疾病有关。本研究的目的是回顾关于使用梭菌菌株作为益生菌的可能性的报告，考虑它们对人类健康的积极影响，并确定与其致病特性表达相关的风险。
