Gu Wan-Jie, Pei Jun-Peng, Lyu Jun, Akimoto Naohiko, Haruki Koichiro, Ogino Shuji, Zhang Chun-Dong
Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing 100142, China.
Cancers (Basel). 2022 Jul 19;14(14):3502. doi: 10.3390/cancers14143502.
The incidence of early-onset colorectal cancer (CRC) diagnosed before age 50 has been increasing over the past decades. Hence, we examined the global, regional, and national burden of early-onset CRC and its risk factors from 1990 to 2019.
Using data from the Global Burden of Disease (GBD) Study 2019, we reported the incidence, deaths, and disability-adjusted life-years (DALYs) attributable to the risk factors of early-onset CRC. All estimates were reported with 95% uncertainty intervals (UIs).
The global numbers of early-onset CRC for incidence, deaths, and DALYs in 2019 were 225,736 (95% UI, 207,658 to 246,756), 86,545 (80,162 to 93,431), and 4,259,922 (3,942,849 to 4,590,979), respectively. Despite large variations at the regional and national levels, the global incidence rate, death rate, and DALY rate increased from 1990 to 2019. Diets low in milk, diets low in calcium, and alcohol use were the leading risk factors in 2019. From 1990 to 2019, a high body mass index and high fasting plasma glucose ranked remarkably higher among males and females, while smoking and diets low in fiber ranked lower among both sexes, with a more profound change among females.
Despite large variations in regional and national levels, the global incidence rate, death rate, and DALY rate increased during the past three decades. These findings may provide policymakers with an accurate quantification of the burden of early-onset CRC and targeted identification of those most at risk to mitigate the burden of early-onset CRC.
在过去几十年中，50岁前诊断出的早发性结直肠癌（CRC）发病率一直在上升。因此，我们研究了1990年至2019年全球、区域和国家早发性结直肠癌的负担及其风险因素。
利用《2019年全球疾病负担（GBD）研究》的数据，我们报告了早发性结直肠癌风险因素导致的发病率、死亡率和伤残调整生命年（DALYs）。所有估计值均报告了95%的不确定性区间（UIs）。
2019年全球早发性结直肠癌的发病率、死亡人数和DALYs分别为225,736例（95%UI，207,658至246,756）、86,545例（80,162至93,431）和4,259,922例（3,942,849至4,590,979）。尽管在区域和国家层面存在很大差异，但全球发病率、死亡率和DALY率从1990年到2019年有所上升。低牛奶饮食、低钙饮食和饮酒是2019年的主要风险因素。从1990年到2019年，高体重指数和高空腹血糖在男性和女性中的排名显著上升，而吸烟和低纤维饮食在两性中的排名较低，女性的变化更为显著。
尽管在区域和国家层面存在很大差异，但在过去三十年中，全球发病率、死亡率和DALY率有所上升。这些发现可为政策制定者提供早发性结直肠癌负担的准确量化，并针对性地识别那些风险最高的人群，以减轻早发性结直肠癌的负担。
