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当前医用纳米颗粒的毒理学关注

Toxicologic Concerns with Current Medical Nanoparticles.

机构信息

Graduate Institute for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.

Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan.

出版信息

Int J Mol Sci. 2022 Jul 8;23(14):7597. doi: 10.3390/ijms23147597.

Abstract

Nanotechnology is one of the scientific advances in technology. Nanoparticles (NPs) are small materials ranging from 1 to 100 nm. When the shape of the supplied nanoparticles changes, the physiological response of the cells can be very different. Several characteristics of NPs such as the composition, surface chemistry, surface charge, and shape are also important parameters affecting the toxicity of nanomaterials. This review covered specific topics that address the effects of NPs on nanomedicine. Furthermore, mechanisms of different types of nanomaterial-induced cytotoxicities were described. The distributions of different NPs in organs and their adverse effects were also emphasized. This review provides insight into the scientific community interested in nano(bio)technology, nanomedicine, and nanotoxicology. The content may also be of interest to a broad range of scientists.

摘要

纳米技术是科技进步的一个领域。纳米粒子(NPs)是尺寸在 1 到 100nm 之间的微小材料。当提供的纳米粒子的形状发生变化时,细胞的生理反应可能会非常不同。纳米粒子的一些特性,如组成、表面化学、表面电荷和形状,也是影响纳米材料毒性的重要参数。这篇综述涵盖了特定的主题,涉及 NPs 对纳米医学的影响。此外,还描述了不同类型的纳米材料诱导细胞毒性的机制。不同 NPs 在器官中的分布及其不良影响也得到了强调。这篇综述为对纳米(生物)技术、纳米医学和纳米毒理学感兴趣的科学界提供了深入了解。其内容也可能引起广泛科学家的兴趣。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08ac/9322368/188da7faa8f6/ijms-23-07597-g001.jpg

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