Li Danyang, Liu Meng, Li Wenyao, Fu Qiang, Wang Liyang, Lai Enping, Zhao Weixin, Zhang Kaile
The Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
School of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
Pharmaceuticals (Basel). 2022 Jun 21;15(7):769. doi: 10.3390/ph15070769.
In recent years, Prussian blue nanoparticles (PBNPs), also named Prussian blue nano-enzymes, have been shown to demonstrate excellent multi-enzyme simulation activity and anti-inflammatory properties, and can be used as reactive oxygen scavengers. Their good biocompatibility and biodegradability mean that they are ideal candidates for in vivo use. PBNPs are highly efficient electron transporters with oxidation and reduction activities. PBNPs also show considerable promise as nano-drug carriers and biological detection sensors owing to their huge specific surface area, good chemical characteristics, and changeable qualities, which might considerably increase the therapeutic impact. More crucially, PBNPs, as therapeutic and diagnostic agents, have made significant advances in biological nanomedicine. This review begins with a brief description of the synthesis methods of PBNPs, then focuses on the applications of PBNPs in tissue regeneration and inflammation according to the different properties of PBNPs. This article will provide a timely reference for further study of PBNPs as therapeutic agents.
近年来，普鲁士蓝纳米颗粒（PBNPs），也被称为普鲁士蓝纳米酶，已被证明具有出色的多酶模拟活性和抗炎特性，并且可用作活性氧清除剂。它们良好的生物相容性和生物降解性意味着它们是体内应用的理想候选物。PBNPs是具有氧化和还原活性的高效电子转运体。由于其巨大的比表面积、良好的化学特性和可变的性质，PBNPs作为纳米药物载体和生物检测传感器也显示出相当大的前景，这可能会大大提高治疗效果。更关键的是，PBNPs作为治疗和诊断剂，在生物纳米医学方面取得了重大进展。本文首先简要描述了PBNPs的合成方法，然后根据PBNPs的不同特性重点介绍了PBNPs在组织再生和炎症中的应用。本文将为进一步研究PBNPs作为治疗剂提供及时的参考。
