Nordin Nur Nadhirah, Aziz Nur Karimah, Naharudin Idanawati, Anuar Nor Khaizan
Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam 42300, Selangor, Malaysia.
Non-Destructive Biomedical and Pharmaceutical Research Centre, Smart Manufacturing Research Institute, Universiti Teknologi MARA, Puncak Alam 42300, Selangor, Malaysia.
Polymers (Basel). 2022 Jul 15;14(14):2873. doi: 10.3390/polym14142873.
This study aims to examine the influence of drug-free pectin hydrogel films on partial-thickness burn wounds using streptozotocin-induced diabetic rats as the animal model. Thirty male Sprague Dawley rats were included in the wound healing study, and scalding water was used to produce wounds in the dorsum region of the rats. Two different formulations of pectin hydrogel films, PH 2.5% and PH 5%, were prepared using a solvent evaporation method. MEBO (moist exposed burn ointment), a commercial herbal formulation was used as a positive control. The progress of the wound healing was observed and compared between untreated normal rats, untreated diabetic rats, diabetic rats treated with MEBO, diabetic rats treated with PH 2.5%, and diabetic rats treated with PH 5%. The results showed that diabetic rats treated with PH 5% healed faster than the untreated diabetic rats and diabetic rats treated with PH 2.5%. Interestingly, the diabetic rats treated with PH 5% healed as well as diabetic rats treated with MEBO, where wounds were healed entirely on day 20. Nevertheless, both PH 2.5% and PH 5% showed a greater zone of inhibition than MEBO when tested against .
本研究旨在以链脲佐菌素诱导的糖尿病大鼠为动物模型，研究不含药物的果胶水凝胶膜对部分厚度烧伤创面的影响。30只雄性斯普拉格-道利大鼠被纳入伤口愈合研究，用烫伤水在大鼠背部区域制造伤口。采用溶剂蒸发法制备了两种不同配方的果胶水凝胶膜，即2.5%PH和5%PH。湿润烧伤膏（MEBO），一种商业草药配方，用作阳性对照。观察并比较了未治疗的正常大鼠、未治疗的糖尿病大鼠、用MEBO治疗的糖尿病大鼠、用2.5%PH治疗的糖尿病大鼠和用5%PH治疗的糖尿病大鼠的伤口愈合进程。结果表明，用5%PH治疗的糖尿病大鼠比未治疗的糖尿病大鼠和用2.5%PH治疗的糖尿病大鼠愈合得更快。有趣的是，用5%PH治疗的糖尿病大鼠与用MEBO治疗的糖尿病大鼠愈合情况相同，在第20天时伤口完全愈合。然而，在针对……进行测试时，2.5%PH和5%PH均显示出比MEBO更大的抑菌圈。
