Department of Nutrition Biology, School of Interdisciplinary and Applied Sciences, Central University of Haryana, Mahendergarh 123031, Haryana, India.
Department of Food Science and Technology, National Institute of Food Technology Entrepreneurship and Management, Kundli, Sonipat 131028, Haryana, India.
Nutrients. 2022 Jul 22;14(15):3001. doi: 10.3390/nu14153001.
Milk-derived bioactive peptides (BAPs) possess several potential attributes in terms of therapeutic capacity and their nutritional value. BAPs from milk proteins can be liberated by bacterial fermentation, in vitro enzymatic hydrolysis, food processing, and gastrointestinal digestion. Previous evidence suggested that milk protein-derived BAPs have numerous health-beneficial characteristics, including anti-cancerous activity, anti-microbial activity, anti-oxidative, anti-hypertensive, lipid-lowering, anti-diabetic, and anti-osteogenic. In this literature overview, we briefly discussed the production of milk protein-derived BAPs and their mechanisms of action. Milk protein-derived BAPs are gaining much interest worldwide due to their immense potential as health-promoting agents. These BAPs are now used to formulate products sold in the market, which reflects their safety as natural compounds. However, enhanced commercialization of milk protein-derived BAPs depends on knowledge of their particular functions/attributes and safety confirmation using human intervention trials. We have summarized the therapeutic potentials of these BAPs based on data from in vivo and in vitro studies.
乳源生物活性肽（BAPs）具有多种治疗能力和营养价值方面的潜在特性。通过细菌发酵、体外酶解、食品加工和胃肠道消化，可以从乳蛋白中释放出 BAPs。先前的证据表明，乳蛋白源 BAPs 具有许多有益健康的特性，包括抗癌活性、抗菌活性、抗氧化、降血压、降血脂、降血糖和抗骨质疏松作用。在这篇文献综述中，我们简要讨论了乳蛋白源 BAPs 的生产及其作用机制。由于其作为促进健康的药物具有巨大的潜力，乳蛋白源 BAPs 在全球范围内引起了广泛关注。这些 BAPs 现在用于配制市场上销售的产品，这反映了它们作为天然化合物的安全性。然而，乳蛋白源 BAPs 的商业化增强取决于对其特定功能/特性的了解，并通过人体干预试验确认其安全性。我们根据体内和体外研究的数据总结了这些 BAPs 的治疗潜力。
