Department of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates.
Nutrients. 2022 Jul 23;14(15):3029. doi: 10.3390/nu14153029.
Neuropathologies, such as neuroinflammaging, have arisen as a serious concern for preserving the quality of life due to the global increase in neurodegenerative illnesses. Nowadays, neuronutraceuticals have gained remarkable attention. It is necessary to investigate the bioavailability, off-target effects, and mechanism of action of neuronutraceuticals. To comprehend the comprehensive impact on brain health, well-designed randomized controlled trials testing combinations of neuronutraceuticals are also necessary. Although there is a translational gap between basic and clinical research, the present knowledge of the molecular perspectives of neuroinflammaging and neuronutraceuticals may be able to slow down brain aging and to enhance cognitive performance. The present review also highlights the key emergent issues, such as regulatory and scientific concerns of neuronutraceuticals, including bioavailability, formulation, blood-brain permeability, safety, and efficacy.
神经病理学，如神经炎症老化，已成为保护生活质量的严重问题，因为全球神经退行性疾病的发病率不断增加。如今，神经营养疗法引起了人们的极大关注。有必要研究神经营养疗法的生物利用度、脱靶效应和作用机制。为了全面了解对大脑健康的影响，还需要进行设计良好的随机对照试验来测试神经营养疗法的组合。尽管基础研究和临床研究之间存在转化差距，但对神经炎症老化和神经营养疗法的分子观点的现有认识，可能有助于减缓大脑衰老和提高认知能力。本综述还强调了神经营养疗法的关键新问题，如监管和科学方面的问题，包括生物利用度、配方、血脑通透性、安全性和疗效。
