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J Invest Dermatol. 2022 Jul;142(7):2003-2013.e5. doi: 10.1016/j.jid.2021.12.018. Epub 2022 Jan 7.
3
FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1-dependent autophagy.成纤维细胞生长因子 21 通过 SIRT1 依赖性自噬促进伤口愈合过程中表皮细胞的迁移和分化。
Br J Pharmacol. 2022 Mar;179(5):1102-1121. doi: 10.1111/bph.15701. Epub 2021 Nov 16.
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A Randomized, Double-Blind, Active- and Placebo-Controlled Trial Evaluating a Novel Topical Treatment for Keloid Scars.一项评价一种新型瘢痕疙瘩局部治疗药物的随机、双盲、阳性药物和安慰剂对照临床试验。
J Drugs Dermatol. 2021 Sep 1;20(9):964-968. doi: 10.36849/jdd.6197.
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NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence.低氧皮肤中的 NK 细胞在伤口愈合和抗菌防御之间进行权衡。
Nat Commun. 2021 Aug 4;12(1):4700. doi: 10.1038/s41467-021-25065-w.
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Fibroblast growth factor in the treatment of burns: A systematic review.成纤维细胞生长因子治疗烧伤：系统评价。
Burns. 2022 Feb;48(1):104-110. doi: 10.1016/j.burns.2021.04.006. Epub 2021 Apr 14.
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bFGF alleviates diabetes-associated endothelial impairment by downregulating inflammation via S-nitrosylation pathway.bFGF 通过 S-亚硝基化途径下调炎症缓解糖尿病相关的内皮功能障碍。
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Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors.饮食诱导的肥胖通过损害皮肤脂肪细胞祖细胞的固有抗菌防御功能促进感染。
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[生长因子对伤口修复调控的研究进展与思考]

[Progress and thoughts on the regulation of wound repair by growth factors].

作者信息

Xiao J, Zhang F

机构信息

Department of Wound Repair, the First Affiliated Hospital of Wenzhou Medical University, Wound Repair and Regenerative Medicine Center, Wenzhou Medical University, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, China.

出版信息

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Jul 20;38(7):610-615. doi: 10.3760/cma.j.cn501225-20220416-00139.

DOI:10.3760/cma.j.cn501225-20220416-00139
PMID:35899329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11704475/
Abstract

Growth factors play an important role in wound healing, and they mainly accelerate wound healing by activating the related signal pathways. Chinese scientists have been conducting basic and clinical researches on growth factors for 30 years, with a series of growth factor drugs being developed and widely used in the treatment of burns and trauma and chronic refractory ulcers. This paper expounds the frontier progress of growth factors on wound healing from the perspectives of immunity, nerve, fat, and so on, and puts forward the further thoughts of the research team on the regulation of wound healing by growth factors.

摘要

生长因子在伤口愈合中发挥着重要作用，它们主要通过激活相关信号通路来加速伤口愈合。中国科学家对生长因子进行基础和临床研究已有30年，研发出一系列生长因子药物并广泛应用于烧伤、创伤及慢性难愈性溃疡的治疗。本文从免疫、神经、脂肪等角度阐述了生长因子在伤口愈合方面的前沿进展，并提出了研究团队对生长因子调控伤口愈合的进一步思考。