Fei Yue, Liu Qi, Peng Na, Yang Guocan, Shen Ziwei, Hong Pan, Wang Shengjun, Rui Ke, Cui Dawei
Shaoxing University School of Medicine, Shaoxing, China.
Department of Hematology, The First Affiliated Hospital of Shaoxing University, Shaoxing, China.
J Immunol Res. 2022 Jul 20;2022:8286498. doi: 10.1155/2022/8286498. eCollection 2022.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects multiple systems. Its clinical manifestation varies across patients, from skin mucosa to multiorgan damage to severe central nervous system involvement. The exosome has been shown to play an important role in the pathogenesis of autoimmune diseases, including SLE. We review the recent knowledge of exosomes, including their biology, functions, mechanism, and standardized extraction and purification methods in SLE, to highlight potential therapeutic targets for SLE.
系统性红斑狼疮（SLE）是一种影响多个系统的全身性自身免疫性疾病。其临床表现因患者而异，从皮肤黏膜病变到多器官损害，再到严重的中枢神经系统受累。已证明外泌体在包括SLE在内的自身免疫性疾病发病机制中发挥重要作用。我们综述了外泌体的最新知识，包括其生物学特性、功能、作用机制以及SLE中外泌体的标准化提取和纯化方法，以突出SLE潜在的治疗靶点。
