Kristoferitsch W, Baumhackl U, Sluga E, Stanek G, Zeiler K
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Feb;263(3):357-64. doi: 10.1016/s0176-6724(87)80093-7.
Clinical data of 19 patients with meningopolyneuritis Garin-Bujadoux-Bannwarth (MPN-GBB), treated with 2 X 10 million units intravenous sodium penicillin for 10 days, were evaluated at the beginning of therapy, 3 weeks thereafter, and 6 months after onset of the neurological disease. Cerebrospinal fluid (CSF) was analysed in 14 patients at the onset of therapy and 3 1/2 weeks thereafter. At the same interval antibodies against B. burgdorferi were measured by enzyme-linked immunosorbent assay (ELISA) in the CSF and sera of 12 patients. Clinical data and all CSF results, with exception of specific antibody titers, were compared with those of patients who had suffered from MPN-GBB between 1979 and 1983, and who had not received antibiotic or corticosteroid therapy. Comparing the clinical data of all treated patients with those of all non-treated controls, no significant difference could be observed. A significant improvement could however be detected in those patients who had their treatment begun 5 weeks within onset of the neurological disease. Changes in CSF 3 1/2 weeks after onset of treatment showed slight differences when compared with controls.
对19例加林-布雅杜-班沃思脑膜多神经炎（MPN-GBB）患者进行了评估，这些患者接受2×1000万单位静脉注射青霉素钠治疗，为期10天，评估时间为治疗开始时、此后3周以及神经疾病发作后6个月。在治疗开始时及此后3.5周，对14例患者的脑脊液（CSF）进行了分析。在相同间隔时间，采用酶联免疫吸附测定（ELISA）法对12例患者的脑脊液和血清中抗伯氏疏螺旋体抗体进行了检测。将临床数据以及除特异性抗体滴度外的所有脑脊液检测结果，与1979年至1983年间患MPN-GBB且未接受抗生素或皮质类固醇治疗的患者的数据进行了比较。将所有接受治疗患者的临床数据与所有未治疗对照组的数据进行比较，未观察到显著差异。然而，在神经疾病发作后5周内开始治疗的患者中可检测到显著改善。治疗开始后3.5周时脑脊液的变化与对照组相比显示出轻微差异。
