DNA 瓦片的断层摄影术影响表面介导的 DNA 自组装的动力学。
Tomography of DNA tiles influences the kinetics of surface-mediated DNA self-assembly.
机构信息
Department of Chemistry, Purdue University, West Lafayette, Indiana.
Department of Chemistry, Purdue University, West Lafayette, Indiana.
出版信息
Biophys J. 2022 Dec 20;121(24):4909-4914. doi: 10.1016/j.bpj.2022.07.025. Epub 2022 Aug 2.
This manuscript studies the impact of extruding hairpins on two-dimensional self-assembly of DNA tiles on solid surface. Hairpins are commonly used as tomographic markers in DNA nanostructures for atomic force microscopy imaging. In this study, we have discovered that hairpins play a more active role. They modulate the adsorption of the DNA tiles onto the solid surface, thus changing the tile assembly kinetics on the solid surface. Based on this discovery, we were able to promote or slow down DNA self-assembly on the surface by changing the hairpin locations on the DNA tiles. This knowledge gained will be helpful for the future design of DNA self-assembly on surface.
这篇手稿研究了发夹对 DNA 瓦片在固体表面上二维自组装的影响。发夹通常被用作原子力显微镜成像中 DNA 纳米结构的断层标记物。在这项研究中，我们发现发夹起着更积极的作用。它们调节 DNA 瓦片在固体表面上的吸附，从而改变瓦片在固体表面上的组装动力学。基于这一发现，我们可以通过改变 DNA 瓦片上发夹的位置来促进或减缓表面上的 DNA 自组装。这一知识的获得将有助于未来在表面上设计 DNA 自组装。
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