Department of Neurology, OLVG, Amsterdam, The Netherlands.
Department of Physical Therapy, OLVG, Amsterdam, The Netherlands.
BMC Neurol. 2022 Aug 4;22(1):289. doi: 10.1186/s12883-022-02805-z.
Patients with a transient ischemic attack (TIA) or ischemic stroke are at increased risk of developing cognitive impairment in the subacute phase. At present, the effects of exercise on cognitive functioning following a TIA or stroke are not fully known. The purpose of this trial was to investigate the effect of exercise on global cognition.
The MoveIT trial is a single-centre, observer-blinded, randomized controlled trial involving a 1-year exercise intervention consisting of a 12-week group exercise program, combined with three counselling visits to the physiotherapists over a 9-month period. The control group received standard care. The primary outcome was global cognitive functioning, assessed at one year, using the Montreal Cognitive Assessment (MoCA). Secondary outcomes included cardiorespiratory fitness, the cardiovascular profile, and attainment of secondary prevention targets, anxiety, depression and fatigue at one and two years.
The experimental group consisted of 60 patients, while the control group consisted of 59 patients. The mean age was 64.3 years and 41% were female. No between-group differences were found on global cognitive functioning (MD, 0.7 out of 30, 95% CI, - 0.2 to 1.6) or on secondary outcome measures at 12 months. The only significant between-group difference was found for fatigue, in favour of the experimental group at 12 months (MD, 0.6 out of 63, 95% CI, 0.1 to 1.1).
No benefit of this exercise intervention was found regarding global cognition. Future studies need to focus on optimizing rehabilitation strategies for this vulnerable group of patients.
http://www.trialregister.nl . Unique identifier: NL3721 . Date first registration: 06-03-2013.
短暂性脑缺血发作（TIA）或缺血性脑卒中患者在亚急性期发生认知障碍的风险增加。目前，运动对 TIA 或脑卒中后认知功能的影响尚不完全清楚。本试验旨在研究运动对整体认知的影响。
MoveIT 试验是一项单中心、观察者盲法、随机对照试验，包括为期 1 年的运动干预，包括为期 12 周的团体运动计划，以及在 9 个月期间与物理治疗师进行 3 次咨询访问。对照组接受标准护理。主要结局是使用蒙特利尔认知评估（MoCA）在 1 年时评估整体认知功能。次要结局包括心肺适能、心血管特征以及在 1 年和 2 年时达到二级预防目标、焦虑、抑郁和疲劳。
实验组有 60 例患者，对照组有 59 例患者。平均年龄为 64.3 岁，41%为女性。两组在整体认知功能（MD，30 分中 0.7 分，95%CI，-0.2 至 1.6）或 12 个月时的次要结局测量上无组间差异。唯一有显著组间差异的是疲劳，实验组在 12 个月时（MD，63 分中 0.6 分，95%CI，0.1 至 1.1）。
本运动干预对整体认知没有益处。未来的研究需要集中优化这一脆弱患者群体的康复策略。
http://www.trialregister.nl。唯一标识符：NL3721。首次注册日期：2013 年 3 月 6 日。
